Livingstone Katherine M, Celis-Morales Carlos, Navas-Carretero Santiago, San-Cristobal Rodrigo, Forster Hannah, O'Donovan Clare B, Woolhead Clara, Marsaux Cyril F M, Macready Anna L, Fallaize Rosalind, Kolossa Silvia, Tsirigoti Lydia, Lambrinou Christina P, Moschonis George, Godlewska Magdalena, Surwiłło Agnieszka, Drevon Christian A, Manios Yannis, Traczyk Iwona, Gibney Eileen R, Brennan Lorraine, Walsh Marianne C, Lovegrove Julie A, Martinez J Alfredo, Saris Wim H M, Daniel Hannelore, Gibney Mike, Mathers John C
1Human Nutrition Research Centre,Institute of Cellular Medicine,Newcastle University,Newcastle Upon Tyne NE1 7RU,UK.
2Center for Nutrition Research,University of Navarra,31008 Pamplona,Spain.
Br J Nutr. 2016 Feb 14;115(3):440-8. doi: 10.1017/S0007114515004675. Epub 2015 Dec 1.
The interplay between the fat mass- and obesity-associated (FTO) gene variants and diet has been implicated in the development of obesity. The aim of the present analysis was to investigate associations between FTO genotype, dietary intakes and anthropometrics among European adults. Participants in the Food4Me randomised controlled trial were genotyped for FTO genotype (rs9939609) and their dietary intakes, and diet quality scores (Healthy Eating Index and PREDIMED-based Mediterranean diet score) were estimated from FFQ. Relationships between FTO genotype, diet and anthropometrics (weight, waist circumference (WC) and BMI) were evaluated at baseline. European adults with the FTO risk genotype had greater WC (AA v. TT: +1·4 cm; P=0·003) and BMI (+0·9 kg/m2; P=0·001) than individuals with no risk alleles. Subjects with the lowest fried food consumption and two copies of the FTO risk variant had on average 1·4 kg/m2 greater BMI (Ptrend=0·028) and 3·1 cm greater WC (Ptrend=0·045) compared with individuals with no copies of the risk allele and with the lowest fried food consumption. However, there was no evidence of interactions between FTO genotype and dietary intakes on BMI and WC, and thus further research is required to confirm or refute these findings.
脂肪量和肥胖相关（FTO）基因变异与饮食之间的相互作用被认为与肥胖的发生有关。本分析的目的是研究欧洲成年人中FTO基因型、饮食摄入量与人体测量学之间的关联。Food4Me随机对照试验的参与者进行了FTO基因型（rs9939609）基因分型，并评估了他们的饮食摄入量，通过食物频率问卷（FFQ）估算饮食质量得分（健康饮食指数和基于PREDIMED的地中海饮食得分）。在基线时评估FTO基因型、饮食与人体测量学指标（体重、腰围（WC）和体重指数（BMI））之间的关系。与没有风险等位基因的个体相比，具有FTO风险基因型的欧洲成年人腰围更大（AA与TT相比：+1.4厘米；P = 0.003），BMI更高（+0.9千克/平方米；P = 0.001）。与没有风险等位基因拷贝且油炸食品消费量最低的个体相比，油炸食品消费量最低且有两份FTO风险变异拷贝的受试者平均BMI高1.4千克/平方米（P趋势= 0.028），腰围大3.1厘米（P趋势= 0.045）。然而，没有证据表明FTO基因型与饮食摄入量在BMI和WC上存在相互作用，因此需要进一步研究来证实或反驳这些发现。
