Centre of Microbial and Plant Genetics, K.U. Leuven, Kasteelpark Arenberg 20, Box 2460, B-3001 Leuven, Belgium.
Trends Microbiol. 2012 Jan;20(1):5-10. doi: 10.1016/j.tim.2011.09.004. Epub 2011 Oct 24.
Lipoteichoic acid (LTA) mutants of lactobacilli suppress inflammation in animal models of experimental colitis. The fact that a single mutation of an administered Lactobacillus strain can result in enhanced probiotic efficacy is surprising given the genetic diversity and complexity of the intestinal niche, but at the same time exciting from a microbiological, immunological and gastroenterological point of view. In this Opinion article, we discuss the possible impacts of LTA modification in probiotic bacteria in the context of the current knowledge regarding the proinflammatory capacity of LTA, structure-activity relationships of LTA, intestinal LTA recognition in healthy and colitis conditions and anti-inflammatory molecules of lactobacilli.
脂磷壁酸（LTA）突变体乳杆菌可抑制实验性结肠炎动物模型的炎症。给予的单一突变乳杆菌菌株可增强益生菌功效，这一事实令人惊讶，因为肠道生态位具有遗传多样性和复杂性，但从微生物学、免疫学和胃肠病学的角度来看，这也令人兴奋。在这篇观点文章中，我们将根据目前关于 LTA 促炎能力、LTA 结构-活性关系、健康和结肠炎条件下肠道 LTA 识别以及乳杆菌抗炎分子的知识，讨论益生菌细菌中 LTA 修饰的可能影响。
