University of California, Los Angeles, Los Angeles, CA, USA.
Cell Cycle. 2011 Oct 15;10(20):3466-72. doi: 10.4161/cc.10.20.17764.
Type 1 diabetes results from the autoimmune destruction of insulin-producing pancreatic β cells. Current efforts to cure diabetes are aimed at replenishing damaged cells by generating a new supply of β cells in vitro. The most promising strategy for achieving this goal is to differentiate embryonic stem (ES) cells by sequentially exposing them to signaling molecules that they would normally encounter in vivo. This approach requires a thorough understanding of the temporal sequence of the signaling events underlying pancreatic β-cell induction during embryonic development. The zebrafish system has emerged as a powerful tool in the study of pancreas development. In this review, we provide a temporal summary of pancreas development in zebrafish with a special focus on the formation of pancreatic β cells.
1 型糖尿病是由产生胰岛素的胰腺β细胞的自身免疫破坏引起的。目前，治愈糖尿病的努力旨在通过在体外产生新的β细胞供应来补充受损的细胞。实现这一目标最有前途的策略是通过顺序暴露胚胎干细胞 (ES) 细胞来分化它们，使其接触到它们在体内通常会遇到的信号分子。这种方法需要深入了解胚胎发育过程中胰腺β细胞诱导的信号事件的时间顺序。斑马鱼系统已成为研究胰腺发育的有力工具。在这篇综述中，我们提供了斑马鱼胰腺发育的时间总结，特别关注胰腺β细胞的形成。
