Frederickson C J, Danscher G
Laboratory for Neurobiology, University of Texas, Dallas 75083.
Prog Brain Res. 1990;83:71-84. doi: 10.1016/s0079-6123(08)61242-x.
Recent advances in metallohistochemistry have substantiated the identification of a distinct class of neurons in the brain, the zinc-containing neurons. These neurons sequester peculiar amounts of zinc in their presynaptic boutons and show both high-affinity uptake and calcium- and impulse-dependent release of the cation. It is thought that the zinc may act to stabilize the storage of certain macromolecules in presynaptic vesicles, but there is also mounting evidence that zinc released from vesicles can produce a broad spectrum of neuromodulatory effects upon target cells. Zinc-containing neurons are found predominantly in limbic and cerebrocortical regions, and a possible role of these neurons in the modification of synaptic strength is considered.
金属组织化学的最新进展证实了大脑中一类独特神经元的存在，即含锌神经元。这些神经元在其突触前终扣中隔离了特定数量的锌，并表现出对阳离子的高亲和力摄取以及钙和冲动依赖性释放。据认为，锌可能起到稳定某些大分子在突触前囊泡中的储存的作用，但也有越来越多的证据表明，从囊泡中释放的锌可对靶细胞产生广泛的神经调节作用。含锌神经元主要存在于边缘和大脑皮质区域，并考虑了这些神经元在突触强度调节中的可能作用。
