Frederickson C J, Hernandez M D, McGinty J F
Laboratory for Neurobiology, University of Texas at Dallas, Richardson 75080.
Brain Res. 1989 Feb 20;480(1-2):317-21. doi: 10.1016/0006-8993(89)90199-6.
Rats were subjected to seizures induced by kainic acid, and the resulting changes in CNS zinc staining were studied with the toluene sulfonamide quinoline fluorescence method. Seizures caused a loss of zinc staining from presynaptic boutons in many limbic and cerebrocortical regions. Simultaneously, the postsynaptic neurons that were degenerating (acidophilic) in those regions as a result of the seizure developed intense fluorescence for zinc. A possible role for zinc in the death of the postsynaptic neurons is suggested.
将大鼠用红藻氨酸诱导癫痫发作，并用甲苯磺酰胺喹啉荧光法研究由此引起的中枢神经系统锌染色变化。癫痫发作导致许多边缘和大脑皮质区域的突触前终扣锌染色缺失。同时，由于癫痫发作而在这些区域发生变性（嗜酸性）的突触后神经元出现强烈的锌荧光。提示锌在突触后神经元死亡中可能起作用。
