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牛生长激素：人类食品安全评估。

Bovine growth hormone: human food safety evaluation.

作者信息

Juskevich J C, Guyer C G

机构信息

Food and Drug Administration, Center for Veterinary Medicine, Office of New Animal Drug Evaluation, Rockville, MD 20857.

出版信息

Science. 1990 Aug 24;249(4971):875-84. doi: 10.1126/science.2203142.

DOI:10.1126/science.2203142
PMID:2203142
Abstract

Scientists in the Food and Drug Administration (FDA), after reviewing the scientific literature and evaluating studies conducted by pharmaceutical companies, have concluded that the use of recombinant bovine growth hormone (rbGH) in dairy cattle presents no increased health risk to consumers. Bovine GH is not biologically active in humans, and oral toxicity studies have demonstrated that rbGH is not orally active in rats, a species responsive to parenterally administered bGH. Recombinant bGH treatment produces an increase in the concentration of insulin-like growth factor-I (IGF-I) in cow's milk. However, oral toxicity studies have shown that bovine IGF-I lacks oral activity in rats. Additionally, the concentration of IGF-I in milk of rbGH-treated cows is within the normal physiological range found in human breast milk, and IGF-I is denatured under conditions used to process cow's milk for infant formula. On the basis of estimates of the amount of protein absorbed intact in humans and the concentration of IGF-I in cow's milk during rbGH treatment, biologically significant levels of intact IGF-I would not be absorbed.

摘要

美国食品药品监督管理局（FDA）的科学家在查阅科学文献并评估制药公司开展的研究后得出结论，认为在奶牛中使用重组牛生长激素（rbGH）不会给消费者带来更高的健康风险。牛生长激素在人体内没有生物活性，口服毒性研究表明，rbGH在大鼠体内没有口服活性，而大鼠是对注射用牛生长激素有反应的物种。重组牛生长激素处理会使牛奶中胰岛素样生长因子-I（IGF-I）的浓度增加。然而，口服毒性研究表明，牛IGF-I在大鼠体内没有口服活性。此外，用重组牛生长激素处理的奶牛所产牛奶中IGF-I的浓度在人母乳的正常生理范围内，并且IGF-I在用于加工婴儿配方奶粉的牛奶的处理条件下会变性。根据对人体完整吸收的蛋白量以及重组牛生长激素处理期间牛奶中IGF-I浓度的估计，不会吸收具有生物学意义水平的完整IGF-I。

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