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Cultured Meat Safety Research Priorities: Regulatory and Governmental Perspectives.

作者信息

Ong Kimberly J, Tejeda-Saldana Yadira, Duffy Breanna, Holmes Dwayne, Kukk Kora, Shatkin Jo Anne

机构信息

Vireo Advisors, LLC, Boston, MA 02130, USA.

New Harvest Canada, Cochrane, AB T4C 0V2, Canada.

出版信息

Foods. 2023 Jul 8;12(14):2645. doi: 10.3390/foods12142645.

DOI:10.3390/foods12142645
PMID:37509737
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10379195/
Abstract

As with every new technology, safety demonstration is a critical component of bringing products to market and gaining public acceptance for cultured meat and seafood. This manuscript develops research priorities from the findings of a series of interviews and workshops with governmental scientists and regulators from food safety agencies in fifteen jurisdictions globally. The interviews and workshops aimed to identify the key safety questions and priority areas of research. Participants raised questions about which aspects of cultured meat and seafood production are novel, and the implications of the paucity of public information on the topic. Novel parameters and targets may require the development of new analytical methods or adaptation and validation of existing ones, including for a diversity of product types and processes. Participants emphasized that data sharing of these efforts would be valuable, similar to those already developed and used in the food and pharmaceutical fields. Contributions to such databases from the private and public sectors would speed general understanding as well as efforts to make evaluations more efficient. In turn, these resources, combined with transparent risk assessment, will be critical elements of building consumer trust in cultured meat and seafood products.

摘要

与每项新技术一样,安全论证是将产品推向市场并获得公众对养殖肉类和海鲜认可的关键组成部分。本手稿根据对全球15个司法管辖区食品安全机构的政府科学家和监管人员进行的一系列访谈和研讨会的结果,制定了研究重点。这些访谈和研讨会旨在确定关键的安全问题和优先研究领域。参与者提出了关于养殖肉类和海鲜生产的哪些方面是新颖的问题,以及该主题的公共信息匮乏所带来的影响。新的参数和指标可能需要开发新的分析方法,或者对现有方法进行调整和验证,包括针对各种产品类型和生产流程。参与者强调,这些工作中的数据共享将是有价值的,类似于食品和制药领域已经开发和使用的数据共享。私营部门和公共部门对这类数据库的贡献将加快人们的普遍理解,并提高评估效率。反过来,这些资源与透明的风险评估相结合,将是建立消费者对养殖肉类和海鲜产品信任的关键要素。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eb2d/10379195/c548aa4daa14/foods-12-02645-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eb2d/10379195/0ac970d410f1/foods-12-02645-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eb2d/10379195/c548aa4daa14/foods-12-02645-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eb2d/10379195/0ac970d410f1/foods-12-02645-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eb2d/10379195/c548aa4daa14/foods-12-02645-g002.jpg

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Foods. 2023 Jul 8;12(14):2645. doi: 10.3390/foods12142645.
2
Food safety considerations and research priorities for the cultured meat and seafood industry.培养肉和海鲜产业的食品安全考虑因素和研究重点。
Compr Rev Food Sci Food Saf. 2021 Nov;20(6):5421-5448. doi: 10.1111/1541-4337.12853. Epub 2021 Oct 10.
3
[Identification of potential hazards and analysis of critical control points in cultured meat production].[ cultured meat 生产中潜在危害的识别与关键控制点分析]
Vopr Pitan. 2023;92(6):45-53. doi: 10.33029/0042-8833-2023-92-6-45-53. Epub 2023 Oct 30.
4
An empirical assessment of common or usual names to label cell-based seafood products.常见或通用名称来标记基于细胞的海鲜产品的实证评估。
J Food Sci. 2020 Aug;85(8):2267-2277. doi: 10.1111/1750-3841.15351. Epub 2020 Jul 20.
5
Review of factors affecting consumer acceptance of cultured meat.影响消费者对实验室培育肉接受度的因素综述。
Appetite. 2022 Mar 1;170:105829. doi: 10.1016/j.appet.2021.105829. Epub 2021 Dec 1.
6
Bringing cultured meat to market: Technical, socio-political, and regulatory challenges in cellular agriculture.将 cultured meat 推向市场:细胞农业中的技术、社会政治和监管挑战。 (注:cultured meat 通常译为“人造肉” 或“实验室培育肉” ,这里按原文保留未译)
Trends Food Sci Technol. 2018 Aug;78:155-166. doi: 10.1016/j.tifs.2018.04.010.
7
The 2023 Latin America report of the Countdown on health and climate change: the imperative for health-centred climate-resilient development.《2023年健康与气候变化倒计时拉丁美洲报告:以健康为中心的气候适应型发展的必要性》
Lancet Reg Health Am. 2024 Apr 23;33:100746. doi: 10.1016/j.lana.2024.100746. eCollection 2024 May.
8
Food product tracing technology capabilities and interoperability.食品追溯技术能力和互操作性。
J Food Sci. 2013 Dec;78 Suppl 2:B28-33. doi: 10.1111/1750-3841.12299. Epub 2013 Nov 21.
9
A comparison of cell-based and cell-cultured as appropriate common or usual names to label products made from the cells of fish.将基于细胞和细胞培养的适当常用名称与标签由鱼类细胞制成的产品进行比较。
J Food Sci. 2021 Sep;86(9):3798-3809. doi: 10.1111/1750-3841.15860. Epub 2021 Aug 1.
10
Cell-based fish production case study for developing a food safety plan.基于细胞的鱼类生产食品安全计划制定案例研究
Heliyon. 2024 Jun 22;10(13):e33509. doi: 10.1016/j.heliyon.2024.e33509. eCollection 2024 Jul 15.

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A global comprehensive review on cultured seafood.关于养殖海产品的全球综合综述。
NPJ Sci Food. 2025 Jul 18;9(1):142. doi: 10.1038/s41538-025-00461-4.
2
Publicly tasting cultivated meat and socially constructing perceived value politics and identity.公开品尝人造肉并在社会层面构建感知到的价值政治与身份认同。
NPJ Sci Food. 2025 Jun 4;9(1):94. doi: 10.1038/s41538-025-00449-0.
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Cell-Based Meat Safety and Regulatory Approaches: A Comprehensive Review.基于细胞的肉类安全性与监管方法:全面综述

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needs a race to mission not a race to market.<此处有图 600ea48097f0f648-7651118184511181>
Food Sci Anim Resour. 2025 Jan;45(1):145-164. doi: 10.5851/kosfa.2024.e122. Epub 2025 Jan 1.
4
Global Insights into Cultured Meat: Uncovering Production Processes, Potential Hazards, Regulatory Frameworks, and Key Challenges-A Scoping Review.对 cultured meat 的全球洞察:揭示生产过程、潜在危害、监管框架和关键挑战——一项范围审查。 (注:这里“cultured meat”一般译为“ cultured meat”,指实验室培育肉,也叫人造肉等,目前国内还没有统一的官方中文译名,暂保留英文表述)
Foods. 2025 Jan 4;14(1):129. doi: 10.3390/foods14010129.
5
A risk-based approach can guide safe cell line development and cell banking for scaled-up cultivated meat production.基于风险的方法可以指导安全的细胞系开发和细胞库建设,以实现规模化的养殖肉类生产。
Nat Food. 2025 Jan;6(1):25-30. doi: 10.1038/s43016-024-01085-9. Epub 2025 Jan 3.
6
Cultivated meat microbiological safety considerations and practices.养殖肉的微生物安全考量与实践
Compr Rev Food Sci Food Saf. 2025 Jan;24(1):e70077. doi: 10.1111/1541-4337.70077.
7
Cell-based fish production case study for developing a food safety plan.基于细胞的鱼类生产食品安全计划制定案例研究
Heliyon. 2024 Jun 22;10(13):e33509. doi: 10.1016/j.heliyon.2024.e33509. eCollection 2024 Jul 15.
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Industrial Research and Development on the Production Process and Quality of Cultured Meat Hold Significant Value: A Review.养殖肉类生产工艺与质量的工业研发具有重要价值:综述
Food Sci Anim Resour. 2024 May;44(3):499-514. doi: 10.5851/kosfa.2024.e20. Epub 2024 May 1.
Nat Food. 2022 Oct;3(10):785-787. doi: 10.1038/s43016-022-00586-9.
2
Techno-economic modeling and assessment of cultivated meat: Impact of production bioreactor scale.培养肉的技术经济建模与评估:生产生物反应器规模的影响
Biotechnol Bioeng. 2023 Apr;120(4):1055-1067. doi: 10.1002/bit.28324. Epub 2023 Jan 19.
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Consumers' perception of cultured meat relative to other meat alternatives and meat itself: A segmentation study.消费者对培养肉相对于其他肉类替代品及肉类本身的认知:一项细分研究。
J Food Sci. 2023 Mar;88(S1):91-105. doi: 10.1111/1750-3841.16372. Epub 2022 Nov 14.
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Risk Assessment of Food Allergens.食物过敏原的风险评估
China CDC Wkly. 2022 Aug 26;4(34):771-774. doi: 10.46234/ccdcw2022.163.
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The Results of Different Heating Temperatures on Activities of Bioactive Proteins in Human Milk.不同加热温度对人乳中生物活性蛋白活性的影响。
J Hum Lact. 2023 May;39(2):300-307. doi: 10.1177/08903344221124870. Epub 2022 Sep 29.
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Dual-Crosslinked Alginate-Based Hydrogels with Tunable Mechanical Properties for Cultured Meat.具有可调机械性能的双交联藻酸盐基水凝胶用于培养肉。
Foods. 2022 Sep 13;11(18):2829. doi: 10.3390/foods11182829.
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Proteomics as a promising biomarker in food authentication, quality and safety: A review.蛋白质组学作为食品认证、质量与安全领域中一种有前景的生物标志物:综述
Food Sci Nutr. 2022 Mar 24;10(7):2333-2346. doi: 10.1002/fsn3.2842. eCollection 2022 Jul.
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Measuring Protein Aggregation and Stability Using High-Throughput Biophysical Approaches.使用高通量生物物理方法测量蛋白质聚集和稳定性
Front Mol Biosci. 2022 May 16;9:890862. doi: 10.3389/fmolb.2022.890862. eCollection 2022.
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The public health issue of antibiotic residues in food and feed: Causes, consequences, and potential solutions.食品和饲料中抗生素残留的公共卫生问题:成因、后果及潜在解决方案。
Vet World. 2022 Mar;15(3):662-671. doi: 10.14202/vetworld.2022.662-671. Epub 2022 Mar 23.
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Recent Advances and Applications of Rapid Microbial Assessment from a Food Safety Perspective.从食品安全角度看快速微生物评估的最新进展与应用
Sensors (Basel). 2022 Apr 6;22(7):2800. doi: 10.3390/s22072800.