Nasonov E L, Samsonov M Iu, Masenko V P, Aleksandrova L Z, Kostin S I, Samko A N, Naumov V G
Ter Arkh. 1990;62(4):72-5.
RIA was used to measure the level of neopterine and beta 2-microglobulin in the sera of 43 patients with a verified diagnosis of dilated cardiomyopathy (DCMP). In DCMP patients, the mean level of neopterine was 11.25 +/- 1.05 nM/l and was significantly higher than in donors (5.6 +/- 0.5 nM/l). The concentration of neopterine exceeding 9 nM/l was discovered in 55% of DCMP patients. The rise of neopterine concentration was particularly marked in patients with inflammatory reaction in the myocardium according to endomyocardial biopsy. In that patients' group, the mean level of neopterine was 12.9 +/- 2.02 nM/l while the rise of its concentration over 9 nM/l was recorded in 9 (81%) of 11 patients examined. The correlation was established between the rise of the concentration of neopterine and beta 2-microglobulin. In patients with the concentration of neopterine over 9 nM/l, the mean level of beta 2-microglobulin constituted 3.33 +/- 0.32 mg/l and in patients with the normal concentration of neopterine, it amounted to 1.91 +/- 0.18 mg/l. The growth of the concentration of beta 2-microglobulin in the groups of patients under comparison was seen in 79 and 14% of cases, respectively. It is concluded that neopterine measurements are advisable in the laboratory diagnosis of myocarditis in DCMP patients. Potential mechanisms of the rise of neopterine formation are discussed from the standpoint of hyperinterferonemia.
放射免疫分析（RIA）用于测量43例确诊为扩张型心肌病（DCMP）患者血清中蝶呤和β2-微球蛋白的水平。在DCMP患者中，蝶呤的平均水平为11.25±1.05nM/l，显著高于献血者（5.6±0.5nM/l）。55%的DCMP患者蝶呤浓度超过9nM/l。根据心内膜心肌活检，心肌有炎症反应的患者蝶呤浓度升高尤为明显。在该患者组中，蝶呤的平均水平为12.9±2.02nM/l，在接受检查的11例患者中有9例（81%）记录到其浓度升高超过9nM/l。蝶呤浓度升高与β2-微球蛋白之间存在相关性。蝶呤浓度超过9nM/l的患者，β2-微球蛋白的平均水平为3.33±0.32mg/l，蝶呤浓度正常的患者，β2-微球蛋白水平为1.91±0.18mg/l。在比较的患者组中，β2-微球蛋白浓度升高分别见于79%和14%的病例。结论是，在DCMP患者心肌炎的实验室诊断中，测量蝶呤是可取的。从高干扰素血症的角度讨论了蝶呤形成增加的潜在机制。
