Nasonov E L, Aleksandrova L Z, Samsonov M Iu, Aleksandrova E N, Gracheva L A
Ter Arkh. 1988;60(7):25-30.
The level of immunoregulatory lymphocytic subpopulations (CD3-, CD4-, CD8-cells, CD4/SD8 ratio, IaDr-positive cells, SD16-cells), lymphocyte natural cytotoxicity (NCT), the concentration of serum interferon (IF), beta 2-microglobulin (beta 2-M) and neopterin were investigated in 30 patients with dilatative cardiomyopathy (DCMP). Immunoregulatory lymphocytic subpopulations were defined by indirect immunofluorescence using monoclonal antibodies to differentiating markers of BMA and OKT series. A decrease in SD4/SD8 ratio less than 1 was observed in 10 patients, an increase in SD4/SD8 ratio over 2.3 was observed in 5 patients. A significant rise of IaDr-positive cells, a decrease in NCT, an increase in the concentration of IF, beta 2-M and neopterin were observed. There was correlation of an increase in IF concentration, the number of IaDr-positive cells and an increase in the level of neopterin and beta 2-M. Signs of activation of the immune system were more frequently noted in patients with a decreased (less than 1) or increased CD4/CD8 ratio. The role of disorders of immunoregulation and activation of the immune system in DCMP pathogenesis was discussed.
对30例扩张型心肌病（DCMP）患者的免疫调节淋巴细胞亚群（CD3 -、CD4 -、CD8 -细胞、CD4/SD8比值、IaDr阳性细胞、SD16细胞）水平、淋巴细胞自然细胞毒性（NCT）、血清干扰素（IF）、β2 -微球蛋白（β2 - M）和新蝶呤浓度进行了研究。免疫调节淋巴细胞亚群通过使用针对BMA和OKT系列分化标志物的单克隆抗体的间接免疫荧光法进行定义。10例患者观察到CD4/SD8比值低于1，5例患者观察到CD4/SD8比值超过2.3。观察到IaDr阳性细胞显著增加、NCT降低、IF、β2 - M和新蝶呤浓度升高。IF浓度升高、IaDr阳性细胞数量以及新蝶呤和β2 - M水平升高之间存在相关性。在CD4/CD8比值降低（小于1）或升高的患者中，更频繁地注意到免疫系统激活的迹象。讨论了免疫调节紊乱和免疫系统激活在DCMP发病机制中的作用。
