有丝分裂后期控制：一场时空探索。
Mitotic exit control: a space and time odyssey.
机构信息
Department of Genetics, University of Cambridge, Cambridge CB2 3EH, UK.
出版信息
Curr Biol. 2011 Oct 25;21(20):R857-9. doi: 10.1016/j.cub.2011.09.023.
PMID:22032192
Abstract
The mitotic exit network (MEN), a protein kinase cascade under the switch-like control of the small GTPase Tem1, triggers exit from mitosis in budding yeast. Now it emerges that signals from both Tem1 and the yeast Polo kinase Cdc5 converge onto the MEN kinase Cdc15 to accurately restrict MEN activation to late mitosis.
摘要
有丝分裂退出网络（MEN）是一种蛋白激酶级联反应，受小分子 GTP 酶 Tem1 的开关样控制，在芽殖酵母中引发有丝分裂退出。现在出现的情况是，来自 Tem1 和酵母 Polo 激酶 Cdc5 的信号都汇聚到 MEN 激酶 Cdc15 上，以将 MEN 的激活准确限制在有丝分裂后期。
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