HIV-1和HIV-2蛋白酶对合成显色底物的水解作用。
Hydrolysis of synthetic chromogenic substrates by HIV-1 and HIV-2 proteinases.
作者信息
Phylip L H, Richards A D, Kay J, Kovalinka J, Strop P, Blaha I, Velek J, Kostka V, Ritchie A J, Broadhurst A V
机构信息
Department of Biochemistry, University of Wales College, Cardiff, U.K.
出版信息
Biochem Biophys Res Commun. 1990 Aug 31;171(1):439-44. doi: 10.1016/0006-291x(90)91412-l.
PMID:2203349
Abstract
Kinetic constants (Km,Kcat) are derived for the hydrolysis of a number of chromogenic peptide substrates by the aspartic proteinase from HIV-2. The effect of systematic replacement of the P2 residue on substrate hydrolysis by HIV-1 and HIV-2 proteinases is examined.
摘要
通过HIV-2天冬氨酸蛋白酶水解多种生色肽底物，得出动力学常数（Km、Kcat）。研究了系统替换P2残基对HIV-1和HIV-2蛋白酶底物水解的影响。
Zotero 插件