Anderson Karen E
Assistant Professor, Psychiatry and Neurology, University of Maryland, School of Medicine, Movement Disorders Division, Department of Neurology, Baltimore, Md, USA.
Dialogues Clin Neurosci. 2004 Sep;6(3):323-32. doi: 10.31887/DCNS.2004.6.3/kanderson.
Treatment of Parkinson's disease (PD) is complex and often involves addressing behavioral changes in addition to the movement disorder. Patients with PD are susceptible to any psychiatric condition seen in the general population; some disorders, such as depression and anxiety, may result from PD-related neuropathological changes. Medicationrelated hallucinations are seen in many PD patients who are treated with dopaminergic agents for motor symptoms. Cognitive impairment is also seen and can be multifactorial. Treatment of behavioral symptoms in PD can greatly improve patients" overall function and quality of life. As surgical interventions to treat motor symptoms, such as deep brain stimulation of the subthalamic nucleus of the substantia nigra, become more prevalent, the behavioral effects of these procedures must also be addressed.
帕金森病(PD)的治疗很复杂,除了运动障碍外,通常还涉及应对行为变化。PD患者易患普通人群中出现的任何精神疾病;某些疾病,如抑郁和焦虑,可能由与PD相关的神经病理变化引起。许多使用多巴胺能药物治疗运动症状的PD患者会出现药物相关幻觉。认知障碍也很常见,且可能是多因素导致的。PD行为症状的治疗可极大地改善患者的整体功能和生活质量。随着治疗运动症状的手术干预措施,如对黑质丘脑底核进行深部脑刺激,越来越普遍,这些手术的行为影响也必须得到关注。