Department of Epidemiology, Statens Serum Institut, Copenhagen, Denmark.
Department of Microbiological Diagnostics, Statens Serum Institut, Copenhagen, Denmark.
J Med Microbiol. 2012 Jan;61(Pt 1):1-7. doi: 10.1099/jmm.0.034447-0. Epub 2011 Oct 27.
Non-typhoid salmonellosis is one of the most common causes of foodborne illness throughout the world. Serological methods for the diagnosis of Salmonella infections vary widely and the most commonly used test is limited by high running costs as well as low sensitivity and specificity. Fast and reliable immunoassays which detect subunit antigens for Salmonella enterica subsp. enterica serovar Typhi are commercially available but at present there is no international consensus on similar tests for non-typhoid salmonellosis. In contrast to the veterinary and food sectors, most immunoassays for non-typhoid human Salmonella diagnosis are developed in-house and used in-house for research or surveillance purposes, rather than for routine diagnostics. Considering the current burden of disease, the development of a validated and standardized, commercially available antibody assay for diagnosing non-typhoid human salmonellosis could be of great benefit for diagnostic and surveillance purposes throughout the world.
非伤寒型沙门氏菌病是全世界最常见的食源性疾病病因之一。用于诊断沙门氏菌感染的血清学方法差异很大，而最常用的检测方法由于运行成本高以及灵敏度和特异性低而受到限制。快速可靠的免疫检测方法可检测肠沙门氏菌亚种肠亚种伤寒血清型的亚单位抗原，但目前对于非伤寒型沙门氏菌病尚无国际共识的类似检测方法。与兽医和食品部门相比，大多数用于非伤寒型人类沙门氏菌诊断的免疫检测方法是内部开发的，用于研究或监测目的，而不是常规诊断。考虑到目前的疾病负担，开发一种经过验证和标准化的、商业上可获得的抗体检测方法，用于诊断非伤寒型人类沙门氏菌病，对于全世界的诊断和监测目的都将非常有益。
