Ferguson J
Department of Dermatology, Ninewells Hospital and Medical School, Dundee, Scotland.
Semin Dermatol. 1990 Mar;9(1):47-54.
The photosensitivity dermatitis and actinic reticuloid syndrome (chronic actinic dermatitis) is a common eczematous photodermatosis of unknown aetiology that in severe form is an extremely disabling condition. It is unclear why males are particularly affected. Difficulties in diagnosis arise in patients who have perennial problems in whom clinical photosensitivity may not be volunteered. An additional problem for the clinician is the finding of contact allergy that is frequently multiple, which further complicates the clinical picture that may, in severe cases, present as an erythroderma or a pseudolymphomatous state. Patch testing and phototesting are the key investigations, with broad ultraviolet (UV) waveband sensitivity occurring as a dermatitis rather than a sunburn response. Contact allergy recognition and avoidance, along with photoprotective measures, are helpful in most cases. Photochemotherapy (PUVA) and systemic immunosuppression may be required in those patients who fail to respond. In some cases, spontaneous resolution follows after a number of years.
光敏性皮炎和光化性类网状细胞增多症(慢性光化性皮炎)是一种病因不明的常见湿疹性光皮肤病,严重时是一种极度致残的病症。尚不清楚为何男性受影响尤为严重。对于常年患病且可能未主动提及临床光敏性的患者,诊断存在困难。临床医生面临的另一个问题是发现接触性过敏,这种过敏常常是多重的,这使临床症状进一步复杂化,在严重情况下可能表现为红皮病或假性淋巴瘤状态。斑贴试验和光试验是关键的检查手段,宽紫外线(UV)波段敏感性表现为皮炎而非晒伤反应。识别并避免接触性过敏,同时采取光防护措施,在大多数情况下会有所帮助。对无反应的患者可能需要光化学疗法(补骨脂素紫外线A疗法,PUVA)和全身免疫抑制治疗。在某些情况下,数年后会自行缓解。