Nelson B D
Department of Biochemistry, Arrhenius Laboratory, University of Stockholm, Sweden.
Biochim Biophys Acta. 1990 Jul 25;1018(2-3):275-7. doi: 10.1016/0005-2728(90)90266-7.
Thyroid hormone exerts two types of effect on mitochondria. The first of these is a rapid activation of respiration which takes place within minutes after hormone injection, and is preserved in isolated mitochondria. The second response occurs after 1 to several days of injection and leads to mitochondrial biogenesis and increases in mitochondria mass. The hormone signal for these two responses involves either triiodothyronine (T3)-responsive nuclear genes or a direct action of T3 at mitochondria binding sites.
甲状腺激素对线粒体有两种作用。第一种是呼吸的快速激活，在注射激素后几分钟内发生，并且在分离的线粒体中得以保留。第二种反应在注射1至数天后出现，导致线粒体生物发生和线粒体质量增加。这两种反应的激素信号涉及三碘甲状腺原氨酸（T3）反应性核基因或T3在线粒体结合位点的直接作用。
