Department of Anatomic Pathology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
Histopathology. 2011 Sep;59(3):368-75. doi: 10.1111/j.1365-2559.2011.03945.x.
To analyse the correlation between β-catenin and vascular endothelial growth factor (VEGF) in sporadic desmoid tumours.
The correlation between β-catenin aberrant expression and VEGF overexpression was examined and microvessel density (MVD) assessed by immunohistochemical expression of CD31 in 74 samples (63 primary and 11 recurrent samples, 63 patients) of sporadic desmoid tumours without familial adenomatous polyposis (FAP). β-catenin gene mutation and mRNA expression of VEGF was then examined by quantitative reverse transcriptase-polymerase chain reaction (RT-PCR). There was a statistically significant correlation between widespread nuclear expression of β-catenin and overexpression of VEGF in all desmoid tumours (P = 0.04, Fisher's exact test). MVD in recurrent tumours was significantly higher than that in primary tumours.
Abnormalities of β-catenin and VEGF overexpression play an important role in the neoplastic progression of sporadic desmoid tumours.
分析散发性硬纤维瘤中β-连环蛋白与血管内皮生长因子（VEGF）之间的相关性。
通过免疫组织化学方法检测 CD31 在 74 例散发性硬纤维瘤（无家族性腺瘤性息肉病（FAP））中的表达，分析β-连环蛋白异常表达与 VEGF 过表达的相关性，并评估微血管密度（MVD）。然后通过定量逆转录聚合酶链反应（RT-PCR）检测β-连环蛋白基因突变和 VEGF 的 mRNA 表达。所有硬纤维瘤中β-连环蛋白广泛核表达与 VEGF 过表达之间存在统计学显著相关性（P = 0.04，Fisher 确切检验）。复发性肿瘤的 MVD 明显高于原发性肿瘤。
β-连环蛋白异常和 VEGF 过表达在散发性硬纤维瘤的肿瘤进展中起重要作用。
