Yakult Central Institute for Microbiological Research, 1796 Yaho, Kunitachi-shi, Tokyo 186-8650, Japan.
J Nat Prod. 2011 Nov 28;74(11):2329-31. doi: 10.1021/np200543z. Epub 2011 Oct 28.
Natural products obtained from marine invertebrates such as sponges and tunicates are attractive sources of drugs. However, a critical obstacle in the development of these compounds is the problem of supply. In most cases, neither chemical synthesis nor mariculture of invertebrates is economically feasible. Due to structural similarities, many marine natural products are suspected to be produced by associated microorganisms. A favorable strategy for the production of such compounds is to use culturable microorganisms. Here we report that didemnin B, a tunicate-derived depsipeptide, has been isolated from a culturable bacterium, Tistrella mobilis YIT 12409.
从海绵和被囊动物等海洋无脊椎动物中获得的天然产物是药物的有吸引力的来源。然而，这些化合物开发的一个关键障碍是供应问题。在大多数情况下，无脊椎动物的化学合成或海水养殖都不具有经济可行性。由于结构相似，许多海洋天然产物被怀疑是由相关微生物产生的。生产此类化合物的一个有利策略是使用可培养的微生物。在这里，我们报告了从可培养细菌 Tistrella mobilis YIT 12409 中分离到的来自被囊动物的衍生出的 depsipeptide 化合物 didemnin B。
