Lee James C, Diamond Joshua M, Christie Jason D
1Penn Lung Transplant Program, Division of Pulmonary, Allergy, and Critical Care Medicine, Perelman School of Medicine at the University of Pennsylvania, 826 West Gates Pavilion, 3400 Spruce Street, Philadelphia, PA 19104 USA.
2Department of Biostatistics and Epidemiology, Division of Pulmonary, Allergy, and Critical Care Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104 USA.
Curr Respir Care Rep. 2012;1(3):168-176. doi: 10.1007/s13665-012-0018-9. Epub 2012 Jun 22.
Lung transplantation provides the prospect of improved survival and quality of life for patients with end stage lung and pulmonary vascular diseases. Given the severity of illness of such patients at the time of surgery, lung transplant recipients require particular attention in the immediate post-operative period to ensure optimal short-term and long-term outcomes. The management of such patients involves active involvement of a multidisciplinary team versed in common post-operative complications. This review provides an overview of such complications as they pertain to the practitioners caring for post-operative lung transplant recipients. Causes and treatment of conditions affecting early morbidity and mortality in lung transplant recipients will be detailed, including primary graft dysfunction, cardiovascular and surgical complications, and immunologic and infectious issues. Additionally, lung donor management issues and bridging the critically ill potential lung transplant recipient to transplantation will be discussed.
肺移植为终末期肺部和肺血管疾病患者提供了提高生存率和生活质量的前景。鉴于此类患者在手术时病情严重，肺移植受者在术后即刻需要特别关注，以确保获得最佳的短期和长期预后。对此类患者的管理需要一个精通常见术后并发症的多学科团队积极参与。本综述概述了与术后肺移植受者护理相关的此类并发症。将详细阐述影响肺移植受者早期发病率和死亡率的病因及治疗方法，包括原发性移植肺功能障碍、心血管和手术并发症以及免疫和感染问题。此外，还将讨论肺供体管理问题以及将重症潜在肺移植受者过渡到移植的问题。
