Ministry of Health, Diskapi Yildirim Beyazit Education and Research Hospital, 3rd Urology Clinic, Ankara, Turkey.
Clin Genitourin Cancer. 2011 Dec;9(2):73-80. doi: 10.1016/j.clgc.2011.07.003.
Much progress has been made toward an understanding of the development and progression of prostate cancer (PC) and the factors that drive the development of androgen independence. Neuroendocrine (NE) cells may provide an intriguing link between NE cell differentiation (NED) and tumor progression in PC. NED in PC generally confers a more aggressive clinical behavior and less favorable prognosis than conventional PC. In this article, we review the known functions of NE cells in PC and discuss the current knowledge on stimulation of cancer proliferation, invasion, apoptosis resistance, serum and immunohistochemical markers, and the prognostic significance of NED in human PC.
在理解前列腺癌（PC）的发展和进展以及驱动雄激素非依赖性发展的因素方面已经取得了很大进展。神经内分泌（NE）细胞可能为 NE 细胞分化（NED）与 PC 中的肿瘤进展之间提供了一个有趣的联系。PC 中的 NED 通常比传统 PC 具有更具侵袭性的临床行为和更差的预后。在本文中，我们综述了已知的 NE 细胞在 PC 中的功能，并讨论了目前关于刺激癌症增殖、侵袭、抗凋亡、血清和免疫组织化学标志物以及 NED 在人 PC 中的预后意义的知识。
