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肺部再生领域的新突破。

A breath of fresh air in lung regeneration.

机构信息

Howard Hughes Medical Institute, Laboratory of Mammalian Cell Biology and Development, The Rockefeller University, New York, NY 10065, USA.

出版信息

Cell. 2011 Oct 28;147(3):485-7. doi: 10.1016/j.cell.2011.10.008.

DOI:10.1016/j.cell.2011.10.008
PMID:22036554
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3289402/
Abstract

Enhancing the ability of the lungs to regenerate following injury could revolutionize the treatment of a wide range of different diseases. In this issue, Kumar et al. (2011) and Ding et al. (2011) dissect the cellular and molecular mechanisms of murine lung regeneration following injury and provide insights into the basic biology of the organ with implications for development of future therapeutic approaches.

摘要

增强肺部在受伤后的再生能力可能会彻底改变多种不同疾病的治疗方式。在本期杂志中,Kumar 等人(2011 年)和 Ding 等人(2011 年)剖析了小鼠肺部受伤后再生的细胞和分子机制,并深入探讨了器官的基本生物学特性,这对未来治疗方法的发展具有重要意义。

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Regenerative pulmonary medicine: potential and promise, pitfalls and challenges.再生医学:潜力与前景、陷阱与挑战。
Eur J Clin Invest. 2012 Aug;42(8):900-13. doi: 10.1111/j.1365-2362.2012.02667.x. Epub 2012 Mar 21.

本文引用的文献

1
Endothelial-derived angiocrine signals induce and sustain regenerative lung alveolarization.内皮细胞衍生的旁分泌信号诱导和维持再生性肺肺泡化。
Cell. 2011 Oct 28;147(3):539-53. doi: 10.1016/j.cell.2011.10.003.
2
Distal airway stem cells yield alveoli in vitro and during lung regeneration following H1N1 influenza infection.远端气道干细胞在体外产生肺泡,并在 H1N1 流感感染后肺再生期间产生肺泡。
Cell. 2011 Oct 28;147(3):525-38. doi: 10.1016/j.cell.2011.10.001.
3
Epithelial progenitor cells in lung development, maintenance, repair, and disease.肺发育、维持、修复和疾病中的上皮祖细胞。
Annu Rev Cell Dev Biol. 2011;27:493-512. doi: 10.1146/annurev-cellbio-100109-104040. Epub 2011 May 31.
4
Evidence for human lung stem cells.人肺干细胞的证据。
N Engl J Med. 2011 May 12;364(19):1795-806. doi: 10.1056/NEJMoa1101324.
5
Basal cells as stem cells of the mouse trachea and human airway epithelium.作为小鼠气管和人类气道上皮干细胞的基底细胞。
Proc Natl Acad Sci U S A. 2009 Aug 4;106(31):12771-5. doi: 10.1073/pnas.0906850106. Epub 2009 Jul 22.
6
The role of Scgb1a1+ Clara cells in the long-term maintenance and repair of lung airway, but not alveolar, epithelium.Scgb1a1⁺克拉拉细胞在肺气道而非肺泡上皮的长期维持和修复中的作用。
Cell Stem Cell. 2009 Jun 5;4(6):525-34. doi: 10.1016/j.stem.2009.04.002.
7
Cellular kinetics and modeling of bronchioalveolar stem cell response during lung regeneration.肺再生过程中支气管肺泡干细胞反应的细胞动力学与建模
Am J Physiol Lung Cell Mol Physiol. 2008 Jun;294(6):L1158-65. doi: 10.1152/ajplung.00298.2007. Epub 2008 Mar 28.
8
FGF9 and SHH regulate mesenchymal Vegfa expression and development of the pulmonary capillary network.成纤维细胞生长因子9(FGF9)和音猬因子(SHH)调节间充质血管内皮生长因子A(Vegfa)的表达及肺毛细血管网络的发育。
Development. 2007 Oct;134(20):3743-52. doi: 10.1242/dev.004879. Epub 2007 Sep 19.
9
Epithelial-vascular cross talk mediated by VEGF-A and HGF signaling directs primary septae formation during distal lung morphogenesis.由血管内皮生长因子A(VEGF-A)和肝细胞生长因子(HGF)信号介导的上皮-血管相互作用指导远端肺形态发生过程中的初级隔膜形成。
Dev Biol. 2007 Aug 1;308(1):44-53. doi: 10.1016/j.ydbio.2007.04.042. Epub 2007 May 3.
10
Basal cells are a multipotent progenitor capable of renewing the bronchial epithelium.基底细胞是一种能够更新支气管上皮的多能祖细胞。
Am J Pathol. 2004 Feb;164(2):577-88. doi: 10.1016/S0002-9440(10)63147-1.