Immunonutrition Research Group, Department of Metabolism and Nutrition, Institute of Food Science, Technology and Nutrition (ICTAN), Spanish National Research Council (CSIC), Madrid, Spain.
Sleep Med. 2011 Dec;12(10):997-1002. doi: 10.1016/j.sleep.2011.05.009. Epub 2011 Oct 28.
To examine the associations between sleep duration and emerging inflammatory and endothelial function risk factors in adolescents.
This study included a total of 183 (88 girls) adolescents, aged 13-17 years, without diagnosed sleep-related disorders. White blood cell counts, C-reactive protein (CRP), complement factors 3 and 4, interleukin-6, adiponectin, leptin, inter-cellular adhesion molecule 1, vascular cell adhesion molecule-1, E-selectin, l-selectin, and plasminogen activator inhibitor-1 were measured. Sleep duration and sleep-related disorders were obtained by self-report and moderate-to-vigorous physical activity (MVPA) was objectively measured by accelerometer. Body mass index (BMI) was calculated from measured height and weight.
A significant inverse association between sleep duration and CRP (β=-0.17, P=0.024) existed only after controlling for sex, age, and pubertal status. The results did not change when MVPA was included into the model. However, the association of sleep duration with CRP was slightly attenuated when BMI was included in the model, though it remained significant (β=-0.15, P=0.044).
Short sleep duration during adolescence might play an important and independent role in cardiovascular and metabolic diseases through CRP.
研究青少年睡眠时间与新兴炎症和内皮功能危险因素之间的关系。
本研究共纳入 183 名（88 名女性）年龄在 13-17 岁、无诊断性睡眠障碍的青少年。通过自我报告测量白细胞计数、C 反应蛋白（CRP）、补体因子 3 和 4、白细胞介素-6、脂联素、瘦素、细胞间黏附分子 1、血管细胞黏附分子-1、E-选择素、L-选择素和纤溶酶原激活物抑制剂-1。通过加速度计客观测量睡眠时间和睡眠障碍，通过测量身高和体重计算体重指数（BMI）。
仅在控制性别、年龄和青春期状态后，睡眠时间与 CRP 之间存在显著的负相关（β=-0.17，P=0.024）。当将 MVPA 纳入模型后，结果没有改变。然而，当 BMI 纳入模型时，睡眠时间与 CRP 的相关性略有减弱，但仍具有统计学意义（β=-0.15，P=0.044）。
青少年时期的睡眠时间较短可能通过 CRP 对心血管和代谢疾病发挥重要的独立作用。
