Sección Genética Evolutiva, Instituto de Biología, Facultad de Ciencias, Igúa 4225, CP11400, Montevideo, Uruguay.
Virus Res. 2012 Jan;163(1):401-4. doi: 10.1016/j.virusres.2011.10.008. Epub 2011 Oct 20.
Canine distemper virus (CDV) is the etiological agent of a multisystemic infection that affects different species of carnivores and is responsible for one of the main diseases suffered by dogs. Recent data have shown a worldwide increase in the incidence of the disease, including in vaccinated dog populations, which necessitates the analysis of circulating strains. The hemagglutinin (H) gene, which encodes the major antigenic viral protein, has been widely used to determine the degree of genetic variability and to associate CDVs in different worldwide circulating lineages. Here, we obtained the sequence of the first full-length H gene of field South American CDV strains and compared it with sequences of worldwide circulating field strains and vaccine viruses. In South America, we detect two co-circulating lineages with different prevalences: the Europe 1 lineage and a new South America 2 lineage. The Europe 1 lineage was the most prevalent in South America, and we suggest renaming it the Europe 1/South America 1 lineage. The South America 2 lineage was found only in Argentina and appears related to wild CDV strains. All South American CDV strains showed high amino-acid divergence from vaccine strains. This genetic variability may be a possible factor leading to the resurgence of distemper cases in vaccinated dog populations.
犬瘟热病毒 (CDV) 是一种全身性感染的病原体，可影响不同种类的食肉动物，是犬类主要疾病之一。最近的数据显示，该疾病在全球范围内的发病率有所增加，包括在已接种疫苗的犬群中，这需要对流行株进行分析。编码主要抗原病毒蛋白的血凝素 (H) 基因已被广泛用于确定遗传变异性程度，并将不同的全球流行谱系中的 CDV 进行关联。在这里，我们获得了南美田间 CDV 毒株的第一个全长 H 基因序列，并将其与全球流行田间毒株和疫苗病毒的序列进行了比较。在南美，我们检测到两种具有不同流行率的共流行谱系：欧洲 1 谱系和新的南美 2 谱系。欧洲 1 谱系在南美更为普遍，我们建议将其重新命名为欧洲 1/南美 1 谱系。南美 2 谱系仅在阿根廷发现，与野生 CDV 株有关。所有南美 CDV 株与疫苗株的氨基酸差异较大。这种遗传变异性可能是导致接种疫苗的犬群中犬瘟热病例再次出现的一个可能因素。
