Sarute Nicolás, Pérez Ruben, Aldaz Jaime, Alfieri Amauri A, Alfieri Alice F, Name Daniela, Llanes Jessika, Hernández Martín, Francia Lourdes, Panzera Yanina
Sección Genética Evolutiva, Instituto de Biología, Facultad de Ciencias, Universidad de la República, Montevideo, Uruguay.
Virus Genes. 2014 Jun;48(3):474-8. doi: 10.1007/s11262-014-1054-z. Epub 2014 Mar 20.
Canine distemper virus (CDV, Paramyxoviridae, Morbillivirus) is the causative agent of a severe infectious disease affecting terrestrial and marine carnivores worldwide. Phylogenetic relationships and the genetic variability of the hemagglutinin (H) protein and the fusion protein signal-peptide (Fsp) allow for the classification of field strains into genetic lineages. Currently, there are nine CDV lineages worldwide, two of them co-circulating in South America. Using the Fsp-coding region, we analyzed the genetic variability of strains from Uruguay, Brazil, and Ecuador, and compared them with those described previously in South America and other geographical areas. The results revealed that the Brazilian and Uruguayan strains belong to the already described South America lineage (EU1/SA1), whereas the Ecuadorian strains cluster in a new clade, here named South America 3, which may represent the third CDV lineage described in South America.
犬瘟热病毒（CDV，副粘病毒科，麻疹病毒属）是一种严重传染病的病原体，影响着全球的陆生和海洋食肉动物。血凝素（H）蛋白和融合蛋白信号肽（Fsp）的系统发育关系及遗传变异性使得能够将野外毒株分类为不同的遗传谱系。目前，全球有九个犬瘟热病毒谱系，其中两个在南美洲共同传播。利用Fsp编码区，我们分析了来自乌拉圭、巴西和厄瓜多尔的毒株的遗传变异性，并将它们与先前在南美洲和其他地理区域描述的毒株进行了比较。结果显示，巴西和乌拉圭的毒株属于已描述的南美谱系（EU1/SA1），而厄瓜多尔的毒株聚集在一个新的分支中，这里命名为南美3，这可能代表了在南美洲描述的第三个犬瘟热病毒谱系。
