Inserm UMR S894, F-75013 Paris, France.
Neurosci Biobehav Rev. 2012 Jan;36(1):696-726. doi: 10.1016/j.neubiorev.2011.10.003. Epub 2011 Oct 20.
This review discusses recent research of mood disorders associated with the cessation of psychoactive substances, with an emphasis on preclinical studies that have been published in the last decade. Animal models exhibiting anhedonic and depressive-like behaviours associated with drug withdrawal have been used to study the neurobiology of mood disorders and have culminated in the identification of novel targets for the treatment of depressive-like symptoms. This review will introduce the behavioural as well as the neurochemical and plasticity changes in depressed patients and several animal models of depression. Following, we provide a more in-depth discussion of the role of serotonergic neurotransmission and Hypothalamic-Pituitary-Adrenal (HPA) axis regulation as well as the neurogenic changes occurring after chronic drug intake focusing on the withdrawal associated depression. Although we mainly focus on animal data, some relevant human studies are also discussed. Establishing the commonalities of depression and drug-seeking behaviour will allow us to elucidate the factors driving the high co-morbidity between mood disorders and drug dependence.
这篇综述讨论了与精神活性物质戒断相关的心境障碍的最新研究进展，重点介绍了过去十年中发表的临床前研究。表现出与药物戒断相关的快感缺失和抑郁样行为的动物模型已被用于研究心境障碍的神经生物学，并最终确定了治疗抑郁样症状的新靶点。这篇综述将介绍抑郁患者和几种抑郁动物模型的行为以及神经化学和可塑性变化。接下来，我们将更深入地讨论 5-羟色胺能神经传递和下丘脑-垂体-肾上腺 (HPA) 轴调节的作用，以及慢性药物摄入后发生的神经发生变化，重点是与戒断相关的抑郁。虽然我们主要关注动物数据，但也讨论了一些相关的人类研究。确定抑郁和觅药行为的共同性将使我们能够阐明导致心境障碍和药物依赖高度共病的因素。
