• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

我从帮助成千上万的人逐渐停用抗抑郁药和其他精神药物中学到的东西。

What I have learnt from helping thousands of people taper off antidepressants and other psychotropic medications.

作者信息

Framer Adele

机构信息

SurvivingAntidepressants.org, San Francisco, California, USA.

出版信息

Ther Adv Psychopharmacol. 2021 Mar 16;11:2045125321991274. doi: 10.1177/2045125321991274. eCollection 2021.

DOI:10.1177/2045125321991274
PMID:33796265
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7970174/
Abstract

Although psychiatric drug withdrawal syndromes have been recognized since the 1950s - recent studies confirm antidepressant withdrawal syndrome incidence upwards of 40% - medical information about how to safely go off the drugs has been lacking. To fill this gap, over the last 25 years, patients have developed a robust Internet-based subculture of peer support for tapering off psychiatric drugs and recovering from withdrawal syndrome. This account from the founder of such an online community covers lessons learned from thousands of patients regarding common experiences with medical providers, identification of adverse drug reactions, risk factors for withdrawal, tapering techniques, withdrawal symptoms, protracted withdrawal syndrome, and strategies to cope with symptoms, in the context of the existing scientific literature.

摘要

尽管自20世纪50年代以来,精神科药物戒断综合征就已被认识到——最近的研究证实,抗抑郁药戒断综合征的发生率超过40%——但关于如何安全停药的医学信息一直匮乏。为了填补这一空白,在过去25年里,患者们形成了一种强大的基于互联网的亚文化,通过同伴支持来逐渐减少精神科药物用量并从戒断综合征中恢复。这个在线社区创始人的叙述,结合现有的科学文献,涵盖了从数千名患者身上吸取的经验教训,内容涉及与医疗服务提供者的常见经历、药物不良反应的识别、戒断的风险因素、逐渐减量技术、戒断症状、迁延性戒断综合征以及应对症状的策略。

相似文献

1
What I have learnt from helping thousands of people taper off antidepressants and other psychotropic medications.我从帮助成千上万的人逐渐停用抗抑郁药和其他精神药物中学到的东西。
Ther Adv Psychopharmacol. 2021 Mar 16;11:2045125321991274. doi: 10.1177/2045125321991274. eCollection 2021.
2
Approaches for discontinuation versus continuation of long-term antidepressant use for depressive and anxiety disorders in adults.成人抑郁和焦虑障碍中长效抗抑郁药停药与继续使用的方法。
Cochrane Database Syst Rev. 2021 Apr 15;4(4):CD013495. doi: 10.1002/14651858.CD013495.pub2.
3
The role of Facebook groups in the management and raising of awareness of antidepressant withdrawal: is social media filling the void left by health services?脸书群组在抗抑郁药物戒断管理及提高认知方面的作用:社交媒体是否正在填补医疗服务留下的空白?
Ther Adv Psychopharmacol. 2021 Jan 17;11:2045125320981174. doi: 10.1177/2045125320981174. eCollection 2021.
4
Designing withdrawal support services for antidepressant users: Patients' views on existing services and what they really need.为抗抑郁药使用者设计戒断支持服务:患者对现有服务的看法及他们真正的需求。
J Psychiatr Res. 2023 May;161:298-306. doi: 10.1016/j.jpsychires.2023.03.013. Epub 2023 Mar 20.
5
Psychotropic Drug Withdrawal and Holistic Tapering Strategies: A Case Series.精神药物戒断与整体逐渐减量策略:病例系列
Adv Mind Body Med. 2019;33(4):4-16.
6
Acute and Persistent Withdrawal Syndromes Following Discontinuation of Psychotropic Medications.精神药物停药后出现的急性和持续戒断综合征。
Psychother Psychosom. 2020;89(5):283-306. doi: 10.1159/000506868. Epub 2020 Apr 7.
7
How user knowledge of psychotropic drug withdrawal resulted in the development of person-specific tapering medication.用户对精神药物戒断的了解如何导致个性化减药方案的制定。
Ther Adv Psychopharmacol. 2020 Jul 10;10:2045125320932452. doi: 10.1177/2045125320932452. eCollection 2020.
8
Successful Discontinuation of Chronic Polypsychotropic Regimen and Resolution of Withdrawal Syndrome Through Nutrition and Lifestyle Interventions: A Case Report.通过营养和生活方式干预成功停用慢性多种精神药物治疗方案并解决戒断综合征:一例报告
Adv Mind Body Med. 2019;33(3):22-30.
9
The long and winding road of discontinuing long-term use of antidepressants: Learning from my experience.停用抗抑郁药长期治疗的漫长曲折之路:从我的经验中学习。
J Psychiatr Ment Health Nurs. 2020 Dec;27(6):850-856. doi: 10.1111/jpm.12623. Epub 2020 Mar 20.
10
The 'patient voice': patients who experience antidepressant withdrawal symptoms are often dismissed, or misdiagnosed with relapse, or a new medical condition.“患者的声音”:经历抗抑郁药物戒断症状的患者常常被忽视,或被误诊为病情复发,或患有新的疾病。
Ther Adv Psychopharmacol. 2020 Nov 9;10:2045125320967183. doi: 10.1177/2045125320967183. eCollection 2020.

引用本文的文献

1
'I Wish It Were More Often Told to People Before They Are Prescribed These Medications How Hard It Is to Get Off Them': A Qualitative Descriptive Analysis of Free-Text Responses to a Survey on Reducing and Stopping Psychiatric Medication.“我希望在给人们开这些药之前,能更经常地告诉他们停药有多难”:对一项关于减少和停用精神科药物的调查的自由文本回复的定性描述性分析
Health Expect. 2025 Aug;28(4):e70384. doi: 10.1111/hex.70384.
2
Fluoxetine substitution for deprescribing antidepressants: a technical approach.用氟西汀替代减停抗抑郁药:一种技术方法。
J Psychiatry Neurosci. 2025 Jul 3;50(4):E202-E209. doi: 10.1503/jpn.250054. Print 2025 Jul-Aug.
3
Post-acute withdrawal syndrome (PAWS) after stopping antidepressants: a systematic review with meta-narrative synthesis.停用抗抑郁药后的急性戒断后综合征(PAWS):一项采用元叙事综合法的系统评价
Epidemiol Psychiatr Sci. 2025 May 13;34:e29. doi: 10.1017/S204579602500023X.
4
The missing link? Pharmacists' perspectives on discontinuation of long-term antidepressants: a qualitative study.缺失的环节?药剂师对停用长期抗抑郁药的看法:一项定性研究。
Ther Adv Psychopharmacol. 2025 Apr 27;15:20451253251333977. doi: 10.1177/20451253251333977. eCollection 2025.
5
A systematic review of manipulations to pharmaceutical dosage forms used in psychotropic tapering plans.对用于精神药物减药计划的药物剂型操作的系统评价。
Br J Clin Pharmacol. 2025 Jul;91(7):1899-1913. doi: 10.1002/bcp.70082. Epub 2025 Apr 27.
6
Hidden Costs: The Clinical and Research Pitfalls of Mistaking Antidepressant Withdrawal for Relapse.隐性成本:将抗抑郁药撤药误认为复发的临床及研究陷阱
Psychother Psychosom. 2025;94(1):3-7. doi: 10.1159/000542437. Epub 2024 Nov 28.
7
Identifying priorities for future research on reducing and stopping psychiatric medication: results of a James Lind Alliance priority-setting partnership.确定减少和停止精神药物使用的未来研究重点:詹姆斯·林德联盟优先事项设定伙伴关系的结果。
BMJ Open. 2024 Nov 5;14(11):e088266. doi: 10.1136/bmjopen-2024-088266.
8
Incidence and risk factors of antidepressant withdrawal symptoms: a meta-analysis and systematic review.抗抑郁药戒断症状的发生率及危险因素:一项荟萃分析与系统评价
Mol Psychiatry. 2025 May;30(5):1758-1769. doi: 10.1038/s41380-024-02782-4. Epub 2024 Oct 11.
9
'We need more support and doctors that understand the process of tapering …': A content analysis of free-text responses to a questionnaire on discontinuing long-term benzodiazepine receptor agonist use.“我们需要更多支持,也需要更多理解停药过程的医生……”:一项对长期苯二氮䓬类受体激动剂停药问卷的自由文本回复的内容分析。
Health Expect. 2024 Feb;27(1):e13962. doi: 10.1111/hex.13962.
10
Gradually tapering off antipsychotics: lessons for practice from case studies and neurobiological principles.逐渐减少抗精神病药物:案例研究和神经生物学原理对实践的启示。
Curr Opin Psychiatry. 2024 Jul 1;37(4):320-330. doi: 10.1097/YCO.0000000000000940. Epub 2024 May 9.

本文引用的文献

1
The role of Facebook groups in the management and raising of awareness of antidepressant withdrawal: is social media filling the void left by health services?脸书群组在抗抑郁药物戒断管理及提高认知方面的作用:社交媒体是否正在填补医疗服务留下的空白?
Ther Adv Psychopharmacol. 2021 Jan 17;11:2045125320981174. doi: 10.1177/2045125320981174. eCollection 2021.
2
Protracted withdrawal syndrome after stopping antidepressants: a descriptive quantitative analysis of consumer narratives from a large internet forum.停用抗抑郁药后的迁延性戒断综合征:来自一个大型网络论坛的消费者叙述的描述性定量分析
Ther Adv Psychopharmacol. 2020 Dec 24;10:2045125320980573. doi: 10.1177/2045125320980573. eCollection 2020.
3
May antidepressant drugs worsen the conditions they are supposed to treat? The clinical foundations of the oppositional model of tolerance.抗抑郁药物会使它们本应治疗的病情恶化吗?耐受性对立模型的临床基础。
Ther Adv Psychopharmacol. 2020 Nov 2;10:2045125320970325. doi: 10.1177/2045125320970325. eCollection 2020.
4
The 'patient voice': patients who experience antidepressant withdrawal symptoms are often dismissed, or misdiagnosed with relapse, or a new medical condition.“患者的声音”:经历抗抑郁药物戒断症状的患者常常被忽视,或被误诊为病情复发,或患有新的疾病。
Ther Adv Psychopharmacol. 2020 Nov 9;10:2045125320967183. doi: 10.1177/2045125320967183. eCollection 2020.
5
Dependence, withdrawal and rebound of CNS drugs: an update and regulatory considerations for new drugs development.中枢神经系统药物的依赖性、戒断反应及反跳现象:新药研发的最新进展与监管考量
Brain Commun. 2019 Oct 16;1(1):fcz025. doi: 10.1093/braincomms/fcz025. eCollection 2019.
6
Tapering Antipsychotic Treatment.逐渐减少抗精神病药物治疗
JAMA Psychiatry. 2021 Feb 1;78(2):125-126. doi: 10.1001/jamapsychiatry.2020.2166.
7
How user knowledge of psychotropic drug withdrawal resulted in the development of person-specific tapering medication.用户对精神药物戒断的了解如何导致个性化减药方案的制定。
Ther Adv Psychopharmacol. 2020 Jul 10;10:2045125320932452. doi: 10.1177/2045125320932452. eCollection 2020.
8
General practitioners' and psychiatrists' attitudes towards antidepressant withdrawal.全科医生和精神科医生对抗抑郁药撤药的态度。
BJPsych Open. 2020 Jun 18;6(4):e64. doi: 10.1192/bjo.2020.48.
9
How effective are antidepressants for depression over the long term? A critical review of relapse prevention trials and the issue of withdrawal confounding.从长期来看,抗抑郁药治疗抑郁症的效果如何?对预防复发试验及撤药混淆问题的批判性综述。
Ther Adv Psychopharmacol. 2020 May 8;10:2045125320921694. doi: 10.1177/2045125320921694. eCollection 2020.
10
The Deceptive Manifestations of Treatment Resistance in Depression: A New Look at the Problem.抑郁症治疗抵抗的欺骗性表现:对该问题的新审视。
Psychother Psychosom. 2020;89(5):265-273. doi: 10.1159/000507227. Epub 2020 Apr 23.