Department of Family Medicine, Gangnam Severance Hospital, College of Medicine, Yonsei University, Seoul, South Korea.
Clin Chim Acta. 2012 Jan 18;413(1-2):319-24. doi: 10.1016/j.cca.2011.10.021. Epub 2011 Oct 19.
The ratio of triglycerides (TG, mg/dl) to high-density lipoprotein cholesterol (HDL-C, mg/dl) is a reliable indicator of insulin resistance and atherosclerotic diseases in some ethnic groups. This study is performed to examine the association between TG/HDL-C and albuminuria.
This cross-sectional study included 9094 adult subjects (4091 men, 5003 women) who were enrolled in the Korean Genomic Rural Cohort (KGRC) and aged 40 years or more. Albuminuria was defined as a urine albumin/creatinine ratio ≥ 30 mg/g. Participants were categorized into TG/HDL-C quartile.
Compared to the lowest TG/HDL-C quartile (<1.94 in men, <1.71 in women), the odds ratios (ORs) for albuminuria in participants who were categorized in the highest TG/HDL-C quartile (≥ 4.98 in men, ≥ 4.20 in women) were 1.30 (95% CI: 0.97-1.75) and 1.36 (1.03-1.79) in men and women, respectively, when adjusted for blood pressure and other covariates. In normotensive men and women, the ORs for albuminuria in the highest TG/HDL-C quartile were 1.58 (1.04-2.39) and 1.68 (1.15-2.45), respectively, even after fully adjusted. In contrast, TG/HDL-C was not associated with albuminuria in hypertensive subjects.
TG/HDL-C was independently associated with increased prevalence of albuminuria in normotensive rural Korean subjects aged 40 years or more in KGRC.
甘油三酯（TG，mg/dl）与高密度脂蛋白胆固醇（HDL-C，mg/dl）的比值是某些族裔人群胰岛素抵抗和动脉粥样硬化疾病的可靠指标。本研究旨在探讨 TG/HDL-C 与白蛋白尿之间的关系。
本横断面研究纳入了韩国农村基因组队列（KGRC）中 9094 名年龄在 40 岁及以上的成年受试者（男性 4091 名，女性 5003 名）。白蛋白尿定义为尿白蛋白/肌酐比值≥30mg/g。参与者被分为 TG/HDL-C 四分位组。
与最低 TG/HDL-C 四分位组（男性<1.94，女性<1.71）相比，男性和女性中被归类于最高 TG/HDL-C 四分位组（男性≥4.98，女性≥4.20）的参与者发生白蛋白尿的比值比（OR）分别为 1.30（95%CI：0.97-1.75）和 1.36（1.03-1.79），校正血压和其他混杂因素后仍如此。在血压正常的男性和女性中，最高 TG/HDL-C 四分位组发生白蛋白尿的 OR 分别为 1.58（1.04-2.39）和 1.68（1.15-2.45），即使在完全校正后仍然如此。相比之下，TG/HDL-C 与高血压患者的白蛋白尿无关。
在年龄在 40 岁及以上的 KGRC 血压正常的韩国农村人群中，TG/HDL-C 与白蛋白尿的患病率升高独立相关。
