Shirane Tokushukai Hospital, 2294-2 Nishino, Minami-Alps, Yamanashi, 400-0213, Japan.
Surg Today. 2012 May;42(5):470-4. doi: 10.1007/s00595-011-0023-6. Epub 2011 Oct 27.
This report presents the case of an 84-year-old woman who developed tetanus 3 days after the resection of a gangrenous small intestine caused by obturator hernia incarceration. The diagnosis of tetanus was clinically made after the appearance of generalized spastic contractions with opisthotonus. Clostridium tetani organisms residing in the gastrointestinal tract were presumed to have been endogenously inoculated into the strangulated intestine, where it produced tetanospasmin, causing tetanus. The patient successfully recovered after aggressive intensive care. There have been 16 case reports of tetanus occurring after gastrointestinal surgical procedures. Primary care physicians should thus be aware of the fact that, although extremely rare, C. tetani residing in the gastrointestinal tract can provide a possible endogenous source of tetanus infection.
本报告介绍了一例 84 岁女性的病例,她在因闭孔疝嵌顿导致的小肠坏疽切除术后 3 天发生破伤风。在出现全身性强直性痉挛伴角弓反张后,临床诊断为破伤风。推测潜伏在胃肠道内的破伤风梭菌通过内源性接种进入绞窄的肠段,并产生破伤风痉挛毒素,引发破伤风。患者经积极强化治疗后成功康复。胃肠道手术后发生破伤风的病例已有 16 例报告。因此,初级保健医生应该意识到,尽管极为罕见,但潜伏在胃肠道内的破伤风梭菌可能为破伤风感染提供一个潜在的内源性来源。