National Cancer Research Network, Leeds, UK.
Ann Oncol. 2011 Nov;22 Suppl 7:vii29-vii35. doi: 10.1093/annonc/mdr423.
In the late 1990 s, in response to poor national cancer survival figures, government monies were invested to enhance recruitment to clinical cancer research. Commencing with England in 2001 and then rolling out across all four countries, a network of clinical cancer research infrastructure was created, the new staff being linked to existing clinical care structures including multi-disciplinary teams. In parallel, a UK-wide co-ordination of cancer research funders driven by the 'virtual' National Cancer Research Institute, combined to create a 'whole-system approach' linking research funders, researchers and NHS clinicians all working to the same ends. Over the next 10 years, recruitment to clinical trials and other well-designed studies, increased 4-fold, reaching 17% of the incident cancer population, the highest national rate world-wide. The additional resources led to more studies opened, and more patients recruited across the country, for all types of cancers and irrespective of additional clinical research staff in some hospitals. In 2006, a co-ordinated decision was made to increasingly focus on randomized trials, leading to increased recruitment, without any fall-off in accrual to non-randomized and observational studies. The National Cancer Research Network has supported large successful trials which are changing clinical practice in many cancers.
20 世纪 90 年代末，为了提高国家癌症生存率，政府投入资金以加强临床癌症研究的人员招聘。2001 年从英格兰开始，然后在四个国家全面展开，建立了一个临床癌症研究基础设施网络，新员工与包括多学科团队在内的现有临床护理结构相联系。与此同时，由“虚拟”国家癌症研究所推动的英国范围内的癌症研究资助者的协调，结合起来创建了一种“全系统方法”，将研究资助者、研究人员和 NHS 临床医生联系起来，共同朝着相同的目标努力。在接下来的 10 年里，临床试验和其他精心设计的研究的参与人数增加了 4 倍，达到了 17%的新发癌症人群，这是全球最高的国家比例。额外的资源导致更多的研究得以开展，全国范围内更多的患者被招募，涵盖了所有类型的癌症，而一些医院的额外临床研究人员则不受影响。2006 年，做出了一项协调一致的决定，即越来越多地关注随机试验，从而增加了参与人数，而不受随机和观察性研究的影响。国家癌症研究网络支持了许多成功的大型试验，这些试验正在改变许多癌症的临床实践。
