Department of Genetics and Center for Medical Informatics, Yale University School of Medicine, New Haven, CT 06520-8005, USA.
Nucleic Acids Res. 2012 Jan;40(Database issue):D1010-5. doi: 10.1093/nar/gkr924. Epub 2011 Oct 28.
ALFRED (http://alfred.med.yale.edu) is a free, web accessible, curated compilation of allele frequency data on DNA sequence polymorphisms in anthropologically defined human populations. Currently, ALFRED has allele frequency tables on over 663,400 polymorphic sites; 170 of them have frequency tables for more than 100 different population samples. In ALFRED, a population may have multiple samples with each 'sample' consisting of many individuals on which an allele frequency is based. There are 3566 population samples from 710 different populations with allele frequency tables on at least one polymorphism. Fifty of those population samples have allele frequency data for over 650,000 polymorphisms. Records also have active links to relevant resources (dbSNP, PharmGKB, OMIM, Ethnologue, etc.). The flexible search options and data display and download capabilities available through the web interface allow easy access to the large quantity of high-quality data in ALFRED.
ALFRED（http://alfred.med.yale.edu）是一个免费的、可通过网络访问的、经过精心整理的人类群体 DNA 序列多态性等位基因频率数据的综合数据库。目前，ALFRED 拥有超过 663,400 个多态性位点的等位基因频率表；其中 170 个位点的频率表包含了超过 100 个不同的人群样本。在 ALFRED 中，一个人群可能有多个样本，每个“样本”由许多个体组成，这些个体的等位基因频率是基于的。有来自 710 个不同人群的 3566 个人群样本，其中至少有一个多态性的等位基因频率表。其中 50 个人群样本具有超过 650,000 个多态性的等位基因频率数据。记录还具有到相关资源（dbSNP、PharmGKB、OMIM、Ethnologue 等）的活动链接。通过网络界面提供的灵活搜索选项、数据显示和下载功能，可轻松访问 ALFRED 中的大量高质量数据。
