Gvatua N A, Mironova O V, Sirenko Iu N, Tolstopiatov S M
Kardiologiia. 1990 Apr;30(4):30-3.
Effects produced both by single intravenous drop-by-drop labetalol, 1 mg/kg (29 patients), sublingual obsidan, 20 mg (14 patients) and a 3-day course treatment with labetalol, 200-600 mg/day, and obsidan (80-160 mg/day) on systemic, intracardiac, and regional hemodynamics and oxygen supply of the body were comparatively studied in 43 patients in early periods of myocardial infarction. As compared with obsidan, labetalol caused favourable hemodynamic changes mostly pronounced in patients with concurrent arterial hypertension. The hemodynamic effects in arterial hypertension were found to come about by virtue of largely an alpha-adrenoblocking effect of the agent whereas in the absence of hypertension it was beneficial due to a combined alpha- and beta-adrenoblocking effect.
