Perepech N B, Saks V A, Nedoshivin A O, Kutuzova A E, Alisova N P
Kardiologiia. 1990 Oct;30(10):52-5.
Changes in the major parameters of central and intracardiac hemodynamics and body's oxygen supply were examined in 93 patients with massive myocardial infarction in the in-hospital period of the disease. Traditional therapy was given to 71 patients; in addition, phosphocreatine infusions (a course dose being 30 g) were used in 22 patients in acute myocardial infarction. Phosphocreatine therapy failed to substantially affect cardiac pump function, but prevented left ventricular dilation and development of congestive heart failure. The patients receiving phosphocreatine showed an increase in body's oxygen consumption due to its elevated tissue extraction. No adverse effects of phosphocreatine were found.
对93例大面积心肌梗死患者在疾病住院期间的中心和心内血流动力学主要参数及机体氧供应变化进行了检查。71例患者接受传统治疗；此外，22例急性心肌梗死患者使用了磷酸肌酸输注（疗程剂量为30g）。磷酸肌酸治疗未能实质性影响心脏泵功能，但预防了左心室扩张和充血性心力衰竭的发展。接受磷酸肌酸治疗的患者由于组织摄取增加，机体耗氧量增加。未发现磷酸肌酸有不良反应。
