Isakov A V, Potin V V, Svechnikova F A, Iumatova T D
Probl Endokrinol (Mosk). 1986 Jan-Feb;32(1):32-5.
Radioimmunoassays were used repeatedly to determine prolactin, LH, FSH, estradiol and progesterone at different time intervals (days, months, weeks) in 50 women with hyperprolactinemic amenorrhea. Nine patients had x-ray signs of hypophysial adenoma. The intact state of the portal system, hypophysis gonadotrophs and thyrotrophs was confirmed using LH-RH and TRH tests. Proceeding from the comparison of gonadotrophin and sex steroids and the analysis of the blood LH fluctuation amplitude after repeated measurements, it was concluded that the gonadotropic basal secretion was disturbed in hyperprolactinemic amenorrhea and that a single determination of an elevated gonadotrophin level in the blood was not enough to diagnose primary ovarian insufficiency.
采用放射免疫分析法，在不同时间间隔（天、月、周）对50例高泌乳素血症闭经患者反复测定泌乳素、促黄体生成素、促卵泡生成素、雌二醇和孕酮。9例患者有垂体腺瘤的X线征象。通过促黄体生成素释放激素（LH-RH）试验和促甲状腺激素释放激素（TRH）试验，证实门脉系统、垂体促性腺细胞和促甲状腺细胞的完整状态。根据促性腺激素和性类固醇的比较以及重复测量后血促黄体生成素波动幅度的分析，得出结论：高泌乳素血症闭经患者的促性腺激素基础分泌受到干扰，单次测定血中促性腺激素水平升高不足以诊断原发性卵巢功能不全。
