Zheng Jia-ju, Shi Xiao-hua, Zhu Xia-shuang, Huangfu Zhao, Guo Zhi-rong
Department of Gastroenterology, Suzhou Municipal Hospital and Suzhou Hospital Affiliated to Nanjing Medical University, Suzhou Institute for Digestive Disease and Nutrition, Suzhou 215008, China.
Zhonghua Nei Ke Za Zhi. 2011 Jul;50(7):597-600.
To collect data and analyze the current status and prevalence changes of Crohn's disease (CD) in mainland China in recent decades.
A computer-based literature search was previously performed by using 50-year (1950 to 2002) of records of CD from the Chinese Database of Biology and Medicine (CBM) (1979 to 2002) and a manual year-by-year search of the literature (1950 to 1978). Using similar method, descriptive epidemiological data from 2003 to 2007 were collected, analyzed and compared with previous research.
Four hundred and seventeen relevant papers during 2003 and 2007 were collected and 62 papers were eligible for inclusion. Within 62 papers, a total of 2149 cases with CD from 2003 to 2007 have been reported nationwide, comprising 1288 male and 861 female patients, with a 1.50:1 male predominance, and indicating 1.41 time of increment as compared with our previous result (ie, 1526 cases from 1950 - 2002). There were no obvious changes in incidence age (younger and middle age were main components) and sex ratio (number of male was still larger than that of female). The extrapolated CD incidence and prevalence rates were 1.21/100 000 person·year and 2.29/100 000, respectively, which were higher than that of year 1950 - 2002, 0.28/100 000 person·year and 1.38/100 000, respectively.
The incidence and prevalence rates of CD have been increasing rapidly, but these rates are still lower than those in Western world.
收集数据并分析近几十年来中国大陆克罗恩病（CD）的现状及流行趋势变化。
此前通过计算机检索中国生物医学文献数据库（CBM）中50年（1950年至2002年）的CD记录（1979年至2002年），并逐年手动检索文献（1950年至1978年）。采用类似方法，收集、分析2003年至2007年的描述性流行病学数据，并与之前的研究进行比较。
收集到2003年至2007年期间417篇相关论文，其中62篇符合纳入标准。在这62篇论文中，全国共报告了2003年至2007年期间2149例CD患者，其中男性1288例，女性861例，男女比例为1.50:1，与我们之前的结果（即1950年至2002年的1526例）相比增加了1.41倍。发病年龄（以中青年为主）和性别比例（男性人数仍多于女性）无明显变化。推算的CD发病率和患病率分别为1.21/10万·人年和2.29/10万，高于1950年至2002年的0.28/10万·人年和1.38/10万。
CD的发病率和患病率一直在迅速上升，但仍低于西方世界。
