Odagiri Keiichi, Uehara Akihiko, Mizuta Isagi, Yamamoto Makoto, Kurata Chinori
YAMAHA Health Care Center, Japan.
Intern Med. 2011;50(21):2491-8. doi: 10.2169/internalmedicine.50.5877. Epub 2011 Nov 1.
Many studies have revealed that white blood cell count (WBC) is related to insulin resistance which is a central mechanism of metabolic syndrome (MetS). However, few cohort studies have examined the role of WBC in the development of MetS. We hypothesized that WBC is associated with the future development of MetS, and investigated the longitudinal incidence of MetS in healthy workers.
WBC was measured in 5,073 workers (mean age 42.5 years) without MetS at baseline. The incidence of MetS was monitored over 7 years of follow-up, in relation to quartiles of WBC. During the follow-up, 925 participants were diagnosed as MetS.
Incidence of MetS was increased in participants with higher WBC: the rates of incidence of MetS were 22.6, 32.9, 42.9, and 57.5 per 1,000 person-years of follow-up in the 1st, 2nd, 3rd, and 4th quartiles of WBC, respectively. After adjustments for confounding factors, the adjusted hazards ratio (95% confidence interval) for MetS was 1.00 (reference), 1.22 (0.98 to 1.51), 1.52 (1.24 to 1.87), and 1.66 (1.35 to 2.04) through the quartiles of WBC, respectively, (p <0.001). This relationship was consistent among current smokers and never smokers, and among male and female genders, respectively.
WBC is useful in predicting the future development of MetS which leads to atherosclerotic diseases.
许多研究表明，白细胞计数（WBC）与胰岛素抵抗相关，而胰岛素抵抗是代谢综合征（MetS）的核心机制。然而，很少有队列研究探讨白细胞在代谢综合征发生发展中的作用。我们推测白细胞与代谢综合征的未来发展有关，并调查了健康工作者中代谢综合征的纵向发病率。
对5073名基线时无代谢综合征的工作者（平均年龄42.5岁）进行白细胞计数测量。在7年的随访期间，监测代谢综合征的发病率与白细胞四分位数的关系。随访期间，925名参与者被诊断为代谢综合征。
白细胞水平较高的参与者中代谢综合征的发病率增加：白细胞四分位数第1、2、3和4组每1000人年随访的代谢综合征发病率分别为22.6、32.9、42.9和57.5。在对混杂因素进行调整后，通过白细胞四分位数，代谢综合征的调整后风险比（95%置信区间）分别为1.00（参考值）、1.22（0.98至1.51）、1.52（1.24至1.87）和1.66（1.35至2.04），（p<0.001）。这种关系在当前吸烟者和从不吸烟者以及男性和女性中分别是一致的。
白细胞有助于预测导致动脉粥样硬化疾病的代谢综合征的未来发展。
