Alfred Hospital and Monash University Central Clinical School, Prahran, VIC, Australia.
Organogenesis. 2011 Jul-Sep;7(3):202-8. doi: 10.4161/org.7.3.18431. Epub 2011 Jul 1.
The planar cell polarity (PCP) pathway plays a critical role in diverse developmental processes that require coordinated cellular movement, including neural tube closure and renal tubulogenesis. Recent studies have demonstrated that this pathway also has emerging relevance to the epidermis, as PCP signaling underpins many aspects of skin biology and pathology, including epidermal development, hair orientation, stem cell division and cancer. Coordinated cellular movement required for epidermal repair in mammals is also regulated by PCP signaling, and in this context, a new PCP gene encoding the developmental transcription factor Grainyhead-like 3 (Grhl3) is critical. This review focuses on the role that PCP signaling plays in the skin across a variety of epidermal functions and highlights perturbations that induce epidermal pathologies.
平面细胞极性 (PCP) 通路在许多需要协调细胞运动的发育过程中发挥着关键作用，包括神经管闭合和肾单位发生。最近的研究表明，该通路与表皮也有新的关联，因为 PCP 信号为许多皮肤生物学和病理学方面提供基础，包括表皮发育、毛发方向、干细胞分裂和癌症。哺乳动物表皮修复所需的协调细胞运动也受 PCP 信号的调节，在这种情况下，一种新的 PCP 基因编码发育转录因子 Grainyhead-like 3 (Grhl3) 至关重要。这篇综述重点介绍了 PCP 信号在各种表皮功能中的作用，并强调了诱导表皮病变的干扰因素。
