Department of Developmental Biology, Washington University School of Medicine in St. Louis, St. Louis, MO 63110, USA.
Dev Cell. 2011 Jul 19;21(1):120-33. doi: 10.1016/j.devcel.2011.06.011.
Planar cell polarization entails establishment of cellular asymmetries within the tissue plane. An evolutionarily conserved planar cell polarity (PCP) signaling system employs intra- and intercellular feedback interactions between its core components, including Frizzled, Van Gogh, Flamingo, Prickle, and Dishevelled, to establish their characteristic asymmetric intracellular distributions and coordinate planar polarity of cell populations. By translating global patterning information into asymmetries of cell membranes and intracellular organelles, PCP signaling coordinates morphogenetic behaviors of individual cells and cell populations with the embryonic polarity. In vertebrates, by polarizing cilia in the node/Kupffer's vesicle, PCP signaling links the anteroposterior to left-right embryonic polarity.
平面细胞极性需要在组织平面内建立细胞不对称性。一个进化保守的平面细胞极性（PCP）信号系统利用其核心成分（包括 Frizzled、Van Gogh、Flamingo、Prickle 和 Dishevelled）之间的细胞内和细胞间反馈相互作用，来建立它们特征性的不对称细胞内分布，并协调细胞群体的平面极性。通过将全局模式信息转化为细胞膜和细胞内细胞器的不对称性，PCP 信号协调单个细胞和细胞群体的形态发生行为与胚胎极性。在脊椎动物中，PCP 信号通过在节点/克普弗氏囊内极化纤毛，将前后到左右的胚胎极性联系起来。
