Huang Yan-Qin, Cai Shan-Rong, Zhang Su-Zhan, Li Qi-Long, Ma Xin-Yuan, He Yu-Fang, Zhou Xiao-Hong, Zheng Shu
Cancer Institute, the Second Affiliated Hospital, Zhejiang University, School of Medicine (Key Laboratory of Cancer Prevention and Intervention, China National Ministry of Education, Key Laboratory of Molecular Biology in Medical Science, Zhejiang Province), Hangzhou 310009, China.
Zhonghua Yu Fang Yi Xue Za Zhi. 2011 Jul;45(7):601-4.
To evaluate a colorectal cancer screening program by tumor detection rate and discussing its application values.
In total, 43 713 subjects were recruited in the screening program who were the registered people aged 40 - 74 in Xiacheng and Jiashan during year 2007 - 2009. The first screening involved questionnaire survey of colorectal cancer related risk factors and fecal occult blood test (FOBT), colonoscopy was performed when a positive result was observed in the first screening. If polyps were found during colonoscopy, biopsy and pathological diagnosis were carried out. The screening data were analyzed and the tumor detection rate was calculated according to age or sex.
6489 subjects (14.85%) belonged to the high risk group of colorectal cancer in the first screening, in which 4701 subjects finished complete colonoscopy. Finally, 569 colorectal neoplasm were diagnosed, the detection rate was 12.10% (95%CI: 11.17% - 13.04%). It included 52 colorectal cancer (1.11%, 95%CI: 0.81% - 1.41%), 183 advanced adenoma (3.89%, 95%CI: 3.34% - 4.45%), 334 non-advanced adenoma (7.10%, 95%CI: 6.37% - 7.84%). The highest detective rate was observed in male group that aged 70 - 74 (22.81%, 95%CI: 16.98% - 28.70%), the lowest detective rate was observed in female group aged 40 - 44 (2.49%, 95%CI: 0.79% - 4.20%).
The current colorectal cancer screening program in China works well, but the revision of the program is necessary.
通过肿瘤检出率评估一项结直肠癌筛查项目，并探讨其应用价值。
在2007年至2009年期间，共招募了43713名研究对象，他们是下城区和嘉善县40 - 74岁的登记居民。首次筛查包括结直肠癌相关危险因素的问卷调查和粪便潜血试验（FOBT），首次筛查结果呈阳性时进行结肠镜检查。如果在结肠镜检查中发现息肉，则进行活检和病理诊断。对筛查数据进行分析，并按年龄或性别计算肿瘤检出率。
首次筛查中6489名研究对象（14.85%）属于结直肠癌高危组，其中4701名研究对象完成了全结肠镜检查。最终，诊断出569例结直肠肿瘤，检出率为12.10%（95%CI：11.17% - 13.04%）。其中包括52例结直肠癌（1.11%，95%CI：0.81% - 1.41%），183例高级别腺瘤（3.89%，95%CI：3.34% - 4.45%），334例非高级别腺瘤（7.10%，95%CI：6.37% - 7.84%）。70 - 74岁男性组的检出率最高（22.81%，95%CI：16.98% - 28.70%），40 - 44岁女性组的检出率最低（2.49%，95%CI：0.79% - 4.20%）。
中国目前的结直肠癌筛查项目效果良好，但该项目仍需修订。
