Soliman M I, Taha H A
Biology Deprtment, Faculty of Science, Taibah University, Saudi Arabia.
Trop Biomed. 2011 Aug;28(2):283-92.
Triclabendazole is the drug of choice against Fasciola infections in humans and animals. However, parasite resistance against triclabendazole is spreading in veterinary field, and there are no drugs of comparable activity currently available for the treatment and control of fascioliasis. The efficacy of a new rhodanine derivative Ro-354 against adult Fasciola gigantica in vitro was investigated. One hour post incubation, scanning and transmission electron microscopic examination revealed an evident disruption of the tegument of F. gigantica as blebbing, swelling and furrowing. Moreover, an increase in severity of tegumental damage as sloughing and absence of spines was observed. In conclusion, Ro-354 shows potent activity against F. gigantica in vitro, and, the authors recommend carrying out more studies to detect its efficacy in vivo.
三氯苯达唑是治疗人和动物片形吸虫感染的首选药物。然而，在兽医领域，寄生虫对三氯苯达唑的耐药性正在蔓延，目前尚无具有类似活性的药物可用于治疗和控制片形吸虫病。研究了一种新型罗丹宁衍生物Ro-354对体外巨大片形吸虫成虫的疗效。孵育1小时后，扫描电子显微镜和透射电子显微镜检查显示，巨大片形吸虫的体表出现明显破坏，表现为起泡、肿胀和起皱。此外，还观察到体表损伤的严重程度增加，如脱落和无棘。总之，Ro-354在体外对巨大片形吸虫显示出强大的活性，作者建议开展更多研究以检测其体内疗效。
