p53 在神经退行性疾病中的作用。
Role of p53 in neurodegenerative diseases.
机构信息
Molecular Studies of Neurodegenerative Diseases Laboratory, Department of Neurology, Temple University School of Medicine, Philadelphia, PA 19140, USA.
出版信息
Neurodegener Dis. 2012;9(2):68-80. doi: 10.1159/000329999. Epub 2011 Oct 28.
BACKGROUND
p53 plays an important role in many areas of cellular physiology and biology, ranging from cellular development and differentiation to cell cycle arrest and apoptosis. Many of its functions are attributed to its role in assuring proper cellular division. However, since the establishment of its role in cell cycle arrest, damage repair, and apoptosis (thus also establishing its importance in cancer development), numerous reports have demonstrated additional functions of p53 in various cells. In particular, p53 appears to have important functions as it relates to neurodegeneration and synaptic plasticity.
OBJECTIVE
In this review, we will address p53 functions as it relates to various neurodegenerative diseases, mainly its implications in the development of HIV-associated neurocognitive disorders.
CONCLUSION
p53 plays a pivotal role in the development of neurodegenerative diseases through its interaction with cellular factors, viral factors, and/or small RNAs that have the ability to promote the development of these diseases. Hence, inhibition of p53 may present an ideal target to restore neuronal functions.
背景
p53 在细胞生理和生物学的许多领域中发挥着重要作用，从细胞发育和分化到细胞周期阻滞和细胞凋亡。其许多功能归因于其在确保细胞正常分裂中的作用。然而，自从确定了 p53 在细胞周期阻滞、损伤修复和细胞凋亡中的作用（因此也确定了其在癌症发展中的重要性）以来，大量报道表明 p53 在各种细胞中具有额外的功能。特别是，p53 似乎在与神经退行性变和突触可塑性相关的方面具有重要功能。
目的
在这篇综述中，我们将讨论 p53 与各种神经退行性疾病相关的功能，主要是其与 HIV 相关神经认知障碍发展的关系。
结论
p53 通过与细胞因子、病毒因子和/或能够促进这些疾病发展的小 RNA 相互作用，在神经退行性疾病的发展中发挥关键作用。因此，抑制 p53 可能为恢复神经元功能提供一个理想的靶点。
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