Department of Orthoptics and Visual Science, Kitasato University School of Allied Health Sciences, 1-15-1 Kitasato, Minami-ku, Sagamihara City, Kanagawa, Japan 252-0373,
Graefes Arch Clin Exp Ophthalmol. 2012 Jun;250(6):935-9. doi: 10.1007/s00417-011-1850-2. Epub 2011 Nov 1.
A modified implantable collamer lens (ICL) with a central hole (diameter, 0.36 mm), a "Hole-ICL", was created to improve aqueous humour circulation. The aim of this study was to investigate the fluid dynamic characteristics of aqueous humour in a Hole-ICL using computational fluid dynamics.
Fluid dynamics simulation using an ICL was performed with thermal-hydraulic analysis software FloEFD V5 (Mentor Graphics Corp.). For the simulation, three-dimensional eye models based on a modified Liou-Brennan model eye with conventional ICL (Model ICM, STAAR SURGICAL) and a Hole-ICL were used. Both ICLs were -9.0 diopters (D) and 12.0 mm in length, with an optic of 5.5 mm. The vaulting was 0.50 mm. The quantity of aqueous humour produced by the ciliary body was set at 2.80 μl/min. Flow distribution between the anterior surface of the crystalline lens and the posterior surface of the ICL was also calculated, and trajectory analysis was performed.
The flow velocity 0.25 mm in front of the centre of the crystalline lens was 1.52 × 10(-1) mm/sec for the Hole-ICL and 1.21 × 10(-5) mm/sec for the conventional ICL. Outward flow from the hole in the Hole-ICL was confirmed by trajectory analysis.
These results suggest that Hole-ICLs improve the circulation of aqueous humour to the anterior surface of the crystalline lens.
为改善房水流通，研发了一种带有中心孔（直径 0.36 毫米）的改良可植入 Collamer 透镜（ICL），即“孔 ICL”。本研究旨在通过计算流体动力学（CFD）研究孔 ICL 中房水的流体动力学特性。
使用热液分析软件 FloEFD V5（Mentor Graphics Corp.）对 ICL 的流体动力学进行模拟。模拟采用基于改良 Liou-Brennan 模型眼的三维眼球模型，该模型眼配备有常规 ICL（STAAR SURGICAL 的 Model ICM）和孔 ICL。两种 ICL 的屈光度均为-9.0D，长度均为 12.0 毫米，光学区为 5.5 毫米，拱高为 0.50 毫米。设定睫状体产生的房水总量为 2.80 μl/min。还计算了晶状体前表面和 ICL 后表面之间的房水分配，并进行了轨迹分析。
在晶状体中心前 0.25 毫米处的流速，孔 ICL 为 1.52×10(-1)mm/sec，常规 ICL 为 1.21×10(-5)mm/sec。通过轨迹分析证实了孔 ICL 中孔的向外流动。
这些结果表明，孔 ICL 可改善房水向晶状体前表面的循环。
