1. Children's Haematology and Cancer Centre, Mount Elizabeth Hospital, Singapore.
J Cancer. 2011;2:527-31. doi: 10.7150/jca.2.527. Epub 2011 Oct 25.
Hepatic sinusoidal obstruction syndrome is commonly described in pediatric oncology as a complication of chemotherapy. It has also been occasionally reported in adult cancer patients. Treatment is largely supportive with fluid restriction. A 16-month-old girl with stage II Wilms tumor receiving post-nephrectomy chemotherapy with dactinomycin and vincristine developed hepatic sinusoidal obstruction syndrome with painful hepatomegaly, ascites with significant weight gain, grossly deranged liver function, severe thrombocytopenia, and reversal of blood flow in the portal vein on Doppler sonography. Treatment with N-acetylcysteine was followed by complete resolution of clinical signs and amelioration of laboratory abnormalities within 72 hours of treatment. N-acetylcysteine is a safe and probably an effective treatment for dactinomycin-induced hepatic sinusoidal obstructive syndrome.
肝窦阻塞综合征在儿科肿瘤学中常被描述为化疗的并发症。它也偶尔在成年癌症患者中报告。治疗主要是支持性的，包括限制液体摄入。一名 16 个月大的 II 期威尔姆斯瘤女孩在接受肾切除术后的化疗，包括放线菌素 D 和长春新碱，出现肝窦阻塞综合征，表现为肝肿大伴疼痛、腹水伴明显体重增加、肝功能严重紊乱、严重血小板减少，以及多普勒超声显示门静脉血流逆转。使用 N-乙酰半胱氨酸治疗后，在治疗后 72 小时内临床症状完全缓解，实验室异常改善。N-乙酰半胱氨酸是一种安全且可能有效的治疗放线菌素 D 诱导的肝窦阻塞综合征的药物。
