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Gradual increase in neuronal density of rats' lateral geniculate nucleus from anterior to posterior.
Neurosciences (Riyadh). 2009 Apr;14(2):124-7.
2
Light stimulus frequency dependence of activity in the rat visual system as studied with high-resolution BOLD fMRI.利用高分辨率血氧水平依赖性功能磁共振成像研究大鼠视觉系统活动的光刺激频率依赖性。
J Neurophysiol. 2006 May;95(5):3164-70. doi: 10.1152/jn.00400.2005. Epub 2006 Jan 4.
3
First research on developmental ambloypia due to early deprivation--Hans Berger's experiments in 1900.
Perception. 2005;34(7):765-7. doi: 10.1068/p3407ed.
4
The cognitive consequences of early sensory deprivation.
Psychosom Med. 1959 Mar-Apr;21(2):89-95. doi: 10.1097/00006842-195903000-00001.
5
Apoptosis and retinal projections in the dorsal lateral geniculate nucleus after monocular deprivation during the later phase of the critical period in the rat.大鼠关键期后期单眼剥夺后背外侧膝状核中的细胞凋亡与视网膜投射
Anat Sci Int. 2003 Jun;78(2):104-10. doi: 10.1046/j.0022-7722.2003.00047.x.
6
Multifaceted roles of nitric oxide in the lateral geniculate nucleus: from visual signal transduction to neuronal apoptosis.一氧化氮在外侧膝状体核中的多方面作用：从视觉信号转导到神经元凋亡。
Toxicol Lett. 2003 Apr 4;139(2-3):163-73. doi: 10.1016/s0378-4274(02)00430-7.
7
Excitotoxic mechanisms of apoptosis in the mammalian visual system following monocular visual deprivation.
Pharmacol Toxicol. 2002 Oct;91(4):153-7. doi: 10.1034/j.1600-0773.2002.910401.x.
8
The role of activity in development of the visual system.活动在视觉系统发育中的作用。
Curr Biol. 2002 Dec 10;12(23):R818-26. doi: 10.1016/s0960-9822(02)01318-0.
9
Apoptosis in the dorsal lateral geniculate nucleus after monocular deprivation involves glutamate signaling, NO production, and PARP activation.单眼剥夺后外侧膝状核中的细胞凋亡涉及谷氨酸信号传导、一氧化氮生成和聚（ADP-核糖）聚合酶激活。
Biochem Biophys Res Commun. 2000 Nov 19;278(2):360-7. doi: 10.1006/bbrc.2000.3811.
10
Neurotoxins affecting neuroexocytosis.影响神经递质胞吐作用的神经毒素。
Physiol Rev. 2000 Apr;80(2):717-66. doi: 10.1152/physrev.2000.80.2.717.

完全剥夺光照对雄性新生大鼠外侧膝状体核的影响。

Effects of total light deprivation on dorsal lateral geniculate nucleus of male neonate rats.

作者信息

Jameie Seyed Behnam E-Din, Abdolrahmani Mohammad, Nobakht Maliheh

出版信息

Oman Med J. 2010 Jul;25(3):179-83. doi: 10.5001/omj.2010.53.

DOI:10.5001/omj.2010.53
PMID:22043334
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3191646/
Abstract

OBJECTIVES

This study examines the effects of total light deprivation on the developing lateral geniculate nucleus, the primary integration centre for visual information

METHODS

Sprague-Dawley rats were reared for one month in a dark room from 7th postnatal day before eye opening. A group of rats was taken back into normal condition for 15 days, and then perfused. Coronal sections of LGN were prepared and stained with Cresyl Violet and Cytochrome Oxidase to investigate the number of neurons, volume and length, as well as neuronal activity level.

RESULTS

The results showed that LD for one month causes progressive loss of neurons and decreases neuronal activity level in the LGN.

CONCLUSION

It can be concluded that during early postnatal development of the rats' visual system, light deprivation causes structural and functional changes in LGN.

摘要

目的

本研究探讨完全剥夺光线对发育中的外侧膝状体核（视觉信息的主要整合中心）的影响。

方法

将出生后第7天睁眼之前的斯普拉格-道利大鼠在暗室中饲养1个月。将一组大鼠放回正常环境15天，然后进行灌注。制备外侧膝状体核的冠状切片，并用甲酚紫和细胞色素氧化酶染色，以研究神经元数量、体积和长度以及神经元活动水平。

结果

结果表明，1个月的光线剥夺导致外侧膝状体核中神经元逐渐丧失，并降低神经元活动水平。

结论

可以得出结论，在大鼠视觉系统出生后早期发育过程中，光线剥夺会导致外侧膝状体核发生结构和功能变化。