完全剥夺光照对雄性新生大鼠外侧膝状体核的影响。
Effects of total light deprivation on dorsal lateral geniculate nucleus of male neonate rats.
作者信息
Jameie Seyed Behnam E-Din, Abdolrahmani Mohammad, Nobakht Maliheh
出版信息
Oman Med J. 2010 Jul;25(3):179-83. doi: 10.5001/omj.2010.53.
Abstract
OBJECTIVES
This study examines the effects of total light deprivation on the developing lateral geniculate nucleus, the primary integration centre for visual information
METHODS
Sprague-Dawley rats were reared for one month in a dark room from 7th postnatal day before eye opening. A group of rats was taken back into normal condition for 15 days, and then perfused. Coronal sections of LGN were prepared and stained with Cresyl Violet and Cytochrome Oxidase to investigate the number of neurons, volume and length, as well as neuronal activity level.
RESULTS
The results showed that LD for one month causes progressive loss of neurons and decreases neuronal activity level in the LGN.
CONCLUSION
It can be concluded that during early postnatal development of the rats' visual system, light deprivation causes structural and functional changes in LGN.
摘要
目的
本研究探讨完全剥夺光线对发育中的外侧膝状体核（视觉信息的主要整合中心）的影响。
方法
将出生后第7天睁眼之前的斯普拉格-道利大鼠在暗室中饲养1个月。将一组大鼠放回正常环境15天，然后进行灌注。制备外侧膝状体核的冠状切片，并用甲酚紫和细胞色素氧化酶染色，以研究神经元数量、体积和长度以及神经元活动水平。
结果
结果表明，1个月的光线剥夺导致外侧膝状体核中神经元逐渐丧失，并降低神经元活动水平。
结论
可以得出结论，在大鼠视觉系统出生后早期发育过程中，光线剥夺会导致外侧膝状体核发生结构和功能变化。
相似文献
1
Effects of total light deprivation on dorsal lateral geniculate nucleus of male neonate rats.完全剥夺光照对雄性新生大鼠外侧膝状体核的影响。
Oman Med J. 2010 Jul;25(3):179-83. doi: 10.5001/omj.2010.53.
2
Gradual increase in neuronal density of rats' lateral geniculate nucleus from anterior to posterior.
Neurosciences (Riyadh). 2009 Apr;14(2):124-7.
3
Effects of sleep deprivation on the postnatal development of visual-deprived cells in the cat's lateral geniculate nucleus.睡眠剥夺对猫外侧膝状核中视觉剥夺细胞产后发育的影响。
Arch Ital Biol. 1995 Dec;134(1):121-40.
4
Molecular and morphological changes in the cat lateral geniculate nucleus and visual cortex induced by visual deprivation are revealed by monoclonal antibodies Cat-304 and Cat-301.单克隆抗体Cat - 304和Cat - 301揭示了视觉剥夺引起的猫外侧膝状体核和视觉皮层的分子和形态学变化。
J Neurosci. 1990 Sep;10(9):3014-24. doi: 10.1523/JNEUROSCI.10-09-03014.1990.
5
c-Fos immunoreactivity in the neurons of the lateral geniculate nucleus in albino rats by light exposure after dark rearing.暗饲养后光照对白化大鼠外侧膝状核神经元中c-Fos免疫反应性的影响
Korean J Ophthalmol. 2011 Dec;25(6):434-9. doi: 10.3341/kjo.2011.25.6.434. Epub 2011 Nov 22.
6
Experience-dependent development of NMDAR1 subunit expression in the lateral geniculate nucleus.外侧膝状核中NMDAR1亚基表达的经验依赖性发育
Vis Neurosci. 1999 Jul-Aug;16(4):781-9. doi: 10.1017/s0952523899164162.
7
Quantitative cellular changes during postnatal development of the rat dorsal lateral geniculate nucleus.
Anat Embryol (Berl). 1986;174(3):321-7. doi: 10.1007/BF00698782.
8
Selective expression and rapid regulation of GABAA receptor subunits in geniculocortical neurons of macaque dorsal lateral geniculate nucleus.猕猴背外侧膝状核膝状皮质神经元中GABAA受体亚基的选择性表达与快速调节
Vis Neurosci. 1996 Mar-Apr;13(2):223-35. doi: 10.1017/s095252380000746x.
9
The effect of altered neuronal activity on the development of layers in the lateral geniculate nucleus.神经元活动改变对外侧膝状体核层发育的影响。
J Neurosci. 1988 Feb;8(2):395-416. doi: 10.1523/JNEUROSCI.08-02-00395.1988.
10
Extended plasticity of visual cortex in dark-reared animals may result from prolonged expression of cpg15-like genes.在黑暗环境中饲养的动物视觉皮层的可塑性增强可能是由于cpg15样基因的长期表达所致。
J Neurosci. 2002 Mar 1;22(5):1807-15. doi: 10.1523/JNEUROSCI.22-05-01807.2002.
引用本文的文献
1
Influence of Sensory Needs on Sleep and Neurodevelopmental Care in At-Risk Neonates.高危新生儿的感官需求对睡眠及神经发育护理的影响
Children (Basel). 2025 Jun 16;12(6):781. doi: 10.3390/children12060781.
2
A of Effects of Environment on Brain Size in Insects.环境对昆虫脑大小影响的A部分。 （你提供的原文“A of Effects of Environment on Brain Size in Insects.”似乎不完整，这里是根据现有内容尽量合理翻译的）
Insects. 2021 May 17;12(5):461. doi: 10.3390/insects12050461.
3
Postretinal Structure and Function in Severe Congenital Photoreceptor Blindness Caused by Mutations in the GUCY2D Gene.GUCY2D基因突变导致的严重先天性光感受器失明患者的视网膜后结构与功能
Invest Ophthalmol Vis Sci. 2017 Feb 1;58(2):959-973. doi: 10.1167/iovs.16-20413.
4
All rodents are not the same: a modern synthesis of cortical organization.并非所有啮齿动物都一样：皮层组织的现代综合研究
Brain Behav Evol. 2011;78(1):51-93. doi: 10.1159/000327320. Epub 2011 Jun 23.
5
Comparison of area 17 cellular composition in laboratory and wild-caught rats including diurnal and nocturnal species.实验室大鼠与野生捕获大鼠（包括昼行性和夜行性物种）视皮层17区细胞组成的比较。
Brain Behav Evol. 2011;77(2):116-30. doi: 10.1159/000324862. Epub 2011 Apr 28.
本文引用的文献
1
Gradual increase in neuronal density of rats' lateral geniculate nucleus from anterior to posterior.
Neurosciences (Riyadh). 2009 Apr;14(2):124-7.
2
Light stimulus frequency dependence of activity in the rat visual system as studied with high-resolution BOLD fMRI.利用高分辨率血氧水平依赖性功能磁共振成像研究大鼠视觉系统活动的光刺激频率依赖性。
J Neurophysiol. 2006 May;95(5):3164-70. doi: 10.1152/jn.00400.2005. Epub 2006 Jan 4.
3
First research on developmental ambloypia due to early deprivation--Hans Berger's experiments in 1900.
Perception. 2005;34(7):765-7. doi: 10.1068/p3407ed.
4
The cognitive consequences of early sensory deprivation.
Psychosom Med. 1959 Mar-Apr;21(2):89-95. doi: 10.1097/00006842-195903000-00001.
5
Apoptosis and retinal projections in the dorsal lateral geniculate nucleus after monocular deprivation during the later phase of the critical period in the rat.大鼠关键期后期单眼剥夺后背外侧膝状核中的细胞凋亡与视网膜投射
Anat Sci Int. 2003 Jun;78(2):104-10. doi: 10.1046/j.0022-7722.2003.00047.x.
6
Multifaceted roles of nitric oxide in the lateral geniculate nucleus: from visual signal transduction to neuronal apoptosis.一氧化氮在外侧膝状体核中的多方面作用：从视觉信号转导到神经元凋亡。
Toxicol Lett. 2003 Apr 4;139(2-3):163-73. doi: 10.1016/s0378-4274(02)00430-7.
7
Excitotoxic mechanisms of apoptosis in the mammalian visual system following monocular visual deprivation.
Pharmacol Toxicol. 2002 Oct;91(4):153-7. doi: 10.1034/j.1600-0773.2002.910401.x.
8
The role of activity in development of the visual system.活动在视觉系统发育中的作用。
Curr Biol. 2002 Dec 10;12(23):R818-26. doi: 10.1016/s0960-9822(02)01318-0.
9
Apoptosis in the dorsal lateral geniculate nucleus after monocular deprivation involves glutamate signaling, NO production, and PARP activation.单眼剥夺后外侧膝状核中的细胞凋亡涉及谷氨酸信号传导、一氧化氮生成和聚（ADP-核糖）聚合酶激活。
Biochem Biophys Res Commun. 2000 Nov 19;278(2):360-7. doi: 10.1006/bbrc.2000.3811.
10
Neurotoxins affecting neuroexocytosis.影响神经递质胞吐作用的神经毒素。
Physiol Rev. 2000 Apr;80(2):717-66. doi: 10.1152/physrev.2000.80.2.717.
Zotero 插件