Sleep and Functional Neurobiology Laboratory, Institute of Nutrition and Food Technology (INTA), University of Chile, Santiago, Chile.
Sleep Med. 2010 Aug;11(7):637-42. doi: 10.1016/j.sleep.2010.03.014.
Iron deficiency anemia (IDA) continues to be the most common single nutrient deficiency in the world. An estimated 20-25% of the world's infants have IDA, with at least as many having iron deficiency without anemia. Infants are at particular risk due to rapid growth and limited dietary sources of iron. We found that infants with IDA showed different motor activity patterning in all sleep-waking states and several differences in sleep states organization. Sleep alterations were still apparent years after correction of anemia with iron treatment in the absence of subsequent IDA. We suggest that altered sleep patterns may represent an underlying mechanism that interferes with optimal brain functioning during sleep and wakefulness in former IDA children.
缺铁性贫血（IDA）仍然是世界上最常见的单一营养素缺乏症。据估计，全世界有 20-25%的婴儿患有 IDA，至少有同样多的婴儿患有缺铁但没有贫血。婴儿由于生长迅速和饮食中铁的来源有限，因此处于特别危险的境地。我们发现，IDA 婴儿在所有睡眠-觉醒状态下的运动活动模式都不同，睡眠状态组织也有几个差异。在缺铁性贫血用铁治疗纠正后数年，即使没有随后发生 IDA，睡眠改变仍然明显。我们认为，睡眠模式的改变可能代表一种潜在的机制，干扰了以前患有 IDA 儿童在睡眠和觉醒期间大脑的最佳功能。
