Polymer Institute, Slovak Academy of Sciences, Centre of Excellence GLYCOMED, Bratislava, Slovakia.
J Mater Sci Mater Med. 2012 Jun;23(6):1457-64. doi: 10.1007/s10856-012-4621-7. Epub 2012 Mar 29.
Poly(2-oxazolines) represent promising polymer materials for biomedical applications. The activation of mouse lymphoid macrophage line P388.D1 (clone 3124) by two selected representatives of poly(2-oxazolines), namely poly(2-ethyl-2-oxazoline) (PETOX100) and poly[2-(4-aminophenyl)-2-oxazoline-co-2-ethyl-2-oxazoline] (AEOX10), was assessed in vitro. The immunomodulatory efficacy of both polymers was evaluated via the induced release of pro-inflammatory cytokines (TNF-α, IL-1α and IL-6) and the acceleration of reactive free radicals. The present study revealed effective structure-immunomodulating associations of AEOX10 and PETOX100, which are desirable in biomedical and pharmaceutical applications of aliphatic and aromatic poly (2-oxazolines) in vivo.
聚（2-恶唑啉）代表了有前途的用于生物医学应用的聚合物材料。通过体外评估两种聚（2-恶唑啉）代表物，即聚（2-乙基-2-恶唑啉）（PETOX100）和聚[2-（4-氨基苯基）-2-恶唑啉-共-2-乙基-2-恶唑啉]（AEOX10），对小鼠淋巴巨噬细胞系 P388.D1（克隆 3124）的激活作用。通过诱导释放促炎细胞因子（TNF-α、IL-1α 和 IL-6）和加速反应性自由基来评估两种聚合物的免疫调节功效。本研究揭示了 AEOX10 和 PETOX100 的有效结构-免疫调节关联，这在体内生物医学和药物应用中对脂肪族和芳香族聚（2-恶唑啉）是理想的。
