Department of Ophthalmology, Royal Children's Hospital, Brisbane, Queensland, Australia.
Clin Exp Ophthalmol. 2012 Jan-Feb;40(1):93-9. doi: 10.1111/j.1442-9071.2011.02724.x. Epub 2011 Dec 23.
To report the incidence of retinopathy of prematurity (ROP) in a subgroup of extremely premature infants admitted to an Australian tertiary centre over an 18-year period.
Retrospective study. Royal Brisbane and Women's Hospital Neonatal Intensive Care Unit.
Five hundred and fifty-four infants admitted between 23 and 25.6 weeks gestational age (GA).
The 18-year study was divided into three 6-year periods for analysis: period 1 (1992-1997), period 2 (1998-2003) and period 3 (2004-2009). Infants were compared based on their week of GA and by the study period in which they were born.
GA, birthweight, incidence and severity of ROP.
Three hundred seventy-three (67.3%) infants survived until ROP screening, and 351 (63.4%) survived until discharge. ROP incidence increased from 78.2% in period 1 to 86.1% in period 3. Over the entire study, 90.5% of 23-week GA infants had ROP compared with 89.7% of 24-week GA infants and 76.1% of 25-week GA infants. Mean birthweight was significantly lower in infants with any ROP (725.1 g) and ROP of at least stage 3 (720.8 g) compared with infants without ROP (806.5 g) (P < 0.0001). Twenty-three-week GA infants had more severe ROP (28.6%) than 24 weeks (18.3%) and 25 weeks GA (11.9%).
There has been increased survival and incidence of ROP in extremely premature infants over the past 20 years. Lower birthweight and GA are both associated with higher incidence and more severe ROP.
报告在澳大利亚一家三级中心接受治疗的早产儿亚组中早产儿视网膜病变（ROP）的发生率。
回顾性研究。皇家布里斯班妇女医院新生儿重症监护病房。
554 名在 23 至 25.6 孕周（GA）入院的婴儿。
这项为期 18 年的研究分为三个 6 年期间进行分析：第 1 期（1992-1997 年）、第 2 期（1998-2003 年）和第 3 期（2004-2009 年）。根据他们的 GA 周和出生时的研究期间对婴儿进行比较。
GA、出生体重、ROP 的发生率和严重程度。
373 名（67.3%）婴儿存活至 ROP 筛查，351 名（63.4%）婴儿存活至出院。ROP 发生率从第 1 期的 78.2%上升至第 3 期的 86.1%。在整个研究中，23 周 GA 婴儿的 ROP 发生率为 90.5%，24 周 GA 婴儿为 89.7%，25 周 GA 婴儿为 76.1%。任何 ROP（725.1g）和至少 3 期 ROP（720.8g）婴儿的平均出生体重明显低于无 ROP 婴儿（806.5g）（P<0.0001）。23 周 GA 婴儿的 ROP 严重程度（28.6%）高于 24 周（18.3%）和 25 周 GA（11.9%）。
在过去的 20 年中，极早产儿的存活率和 ROP 发生率有所增加。较低的出生体重和 GA 均与较高的发生率和更严重的 ROP 相关。
