Department of Pharmacy, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.
J Transl Med. 2011 Nov 1;9:187. doi: 10.1186/1479-5876-9-187.
The target-controlled infusion-III (SLOG/TCI-III) system was derived from a model set up by the local pediatric population for target control infusion of propofol.
The current study aimed at evaluating the difference between target concentrations of propofol and performance, which was measured using the SLOG/TCI-III system in children. Thirty children fulfilling the I-II criteria according to American Society of Anesthesiology were enrolled in the study. The target plasma concentration of propofol was fed into the SLOG/TCI-III system and compared with the measured concentrations of propofol. Blood samples were collected and analyzed by high performance liquid chromatography with fluorescence detector. The performance error (PE) was determined for each measured blood propofol concentration. The performances of the TCI-III system were determined by the median performance error (MDPE), the median absolute performance error (MDAPE), and Wobble (the median absolute deviation of each PE from the MDPE), respectively.
Concentration against target concentration showed good linear correlation: concentration = 1.3428 target concentration - 0.2633 (r = 0.8667). The MDPE and MDAPE of the pediatric system were 10 and 22%, respectively, and the median value for Wobble was 24%. MDPE and MDAPE were less than 15 and 30%, respectively.
The performance of TCI-III system seems to be in the accepted limits for clinical practice in children.
靶控输注-III（SLOG/TCI-III）系统源自针对儿童的丙泊酚靶控输注的本地儿科人群建立的模型。
本研究旨在评估 SLOG/TCI-III 系统在儿童中测量的丙泊酚靶浓度与性能之间的差异。根据美国麻醉医师学会的 I-II 标准，本研究纳入了 30 名儿童。将丙泊酚的目标血浆浓度输入 SLOG/TCI-III 系统，并与测量的丙泊酚浓度进行比较。通过高效液相色谱法-荧光检测器采集和分析血样。确定每个测量的血丙泊酚浓度的性能误差（PE）。通过中位性能误差（MDPE）、中位绝对性能误差（MDAPE）和摆动（每个 PE 与 MDPE 的中位数绝对偏差），分别确定 TCI-III 系统的性能。
浓度与目标浓度呈良好的线性相关：浓度=1.3428×目标浓度-0.2633（r=0.8667）。儿科系统的 MDPE 和 MDAPE 分别为 10%和 22%，中位摆动值为 24%。MDPE 和 MDAPE 分别小于 15%和 30%。
TCI-III 系统的性能似乎在儿童临床实践的可接受范围内。
