“小儿输液泵”在接受心脏手术或心导管插入术患儿中的准确性。
Accuracy of the 'Paedfusor' in children undergoing cardiac surgery or catheterization.
作者信息
Absalom A, Amutike D, Lal A, White M, Kenny G N C
机构信息
University Department of Anaesthesia, Glasgow Royal Infirmary, Queen Elizabeth Building, Alexandra Parade, Glasgow G31 2ER, UK.
出版信息
Br J Anaesth. 2003 Oct;91(4):507-13. doi: 10.1093/bja/aeg220.
BACKGROUND
A prototype paediatric propofol target-controlled infusion (TCI) system, the 'Paedfusor' has been developed. This system incorporates a paediatric pharmacokinetic data set and algorithm specific for children in a Graseby 3500 anaesthesia syringe driver. In this study we have evaluated the accuracy of the Paedfusor TCI system in children who underwent either cardiac surgery or cardiac catheterization procedures.
METHODS
Twenty-nine children aged 1-15 yr were investigated. General anaesthesia was provided using propofol administered by the Paedfusor system. Accuracy of the system was evaluated by obtaining up to 9 arterial samples for measurement of propofol concentration both during anaesthesia and in the recovery period. Measured arterial propofol concentrations were then compared with values calculated by the Paedfusor.
RESULTS
The predictive indices of median performance error (MDPE), and median absolute performance error (MDAPE) of the Paedfusor system were found to be 4.1% and 9.7%, respectively and the median value for wobble was 8.3%. These values are much better than those found with the adult 'Diprifusor' system.
CONCLUSION
The Paedfusor performance was found to be within the accepted limits for use as a TCI system.
背景
已开发出一种儿科丙泊酚靶控输注（TCI）系统原型，即“小儿输注泵”。该系统将儿科药代动力学数据集和针对儿童的算法整合到Graseby 3500麻醉注射器驱动器中。在本研究中，我们评估了小儿输注泵TCI系统在接受心脏手术或心导管插入术的儿童中的准确性。
方法
对29名年龄在1至15岁的儿童进行了研究。使用小儿输注泵系统给予丙泊酚进行全身麻醉。通过在麻醉期间和恢复期获取多达9份动脉样本以测量丙泊酚浓度来评估该系统的准确性。然后将测得的动脉丙泊酚浓度与小儿输注泵计算的值进行比较。
结果
发现小儿输注泵系统的中位性能误差（MDPE）和中位绝对性能误差（MDAPE）的预测指标分别为4.1%和9.7%，摆动的中值为8.3%。这些值比成人“得普利麻输注泵”系统的值要好得多。
结论
发现小儿输注泵的性能在用作TCI系统的可接受范围内。
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