Kesari Kavindra Kumar, Kumar Sanjay, Behari Jitendra
Bioelectromagnetic Laboratory, School of Environmental Sciences, Jawaharlal Nehru University, New Delhi-110067, India.
Electromagn Biol Med. 2011 Dec;30(4):219-34. doi: 10.3109/15368378.2011.587930.
Recently, there have been several reports referring to detrimental effects due to radio frequency electromagnetic fields (RF-EMF) exposure. Special attention was given to investigate the effect of mobile phone exposure on the rat brain. Since the integrative mechanism of the entire body lies in the brain, it is suggestive to analyze its biochemical aspects. For this, 35-day old Wistar rats were exposed to a mobile phone for 2 h per day for a duration of 45 days where specific absorption rate (SAR) was 0.9 W/Kg. Animals were divided in two groups: sham exposed (n = 6) and exposed group (n = 6). Our observations indicate a significant decrease (P < 0.05) in the level of glutathione peroxidase, superoxide dismutase, and an increase in catalase activity. Moreover, protein kinase shows a significant decrease in exposed group (P < 0.05) of hippocampus and whole brain. Also, a significant decrease (P < 0.05) in the level of pineal melatonin and a significant increase (P < 0.05) in creatine kinase and caspase 3 was observed in exposed group of whole brain as compared with sham exposed. Finally, a significant increase in the level of ROS (reactive oxygen species) (P < 0.05) was also recorded. The study concludes that a reduction or an increase in antioxidative enzyme activities, protein kinase C, melatonin, caspase 3, and creatine kinase are related to overproduction of reactive oxygen species (ROS) in animals under mobile phone radiation exposure. Our findings on these biomarkers are clear indications of possible health implications.
最近，有几份报告提到了射频电磁场（RF - EMF）暴露所产生的有害影响。人们特别关注研究手机暴露对大鼠大脑的影响。由于整个身体的整合机制存在于大脑中，因此分析其生化方面是很有意义的。为此，将35日龄的Wistar大鼠每天暴露于手机2小时，持续45天，其中比吸收率（SAR）为0.9W/Kg。动物被分为两组：假暴露组（n = 6）和暴露组（n = 6）。我们的观察结果表明，谷胱甘肽过氧化物酶、超氧化物歧化酶水平显著降低（P < 0.05），而过氧化氢酶活性增加。此外，蛋白激酶在海马体和全脑的暴露组中显著降低（P < 0.05）。而且，与假暴露组相比，全脑暴露组中松果体褪黑素水平显著降低（P < 0.05），肌酸激酶和半胱天冬酶3显著增加（P < 0.05）。最后，还记录到活性氧（ROS）水平显著增加（P < 0.05）。该研究得出结论，抗氧化酶活性、蛋白激酶C、褪黑素、半胱天冬酶3和肌酸激酶的降低或增加与手机辐射暴露下动物体内活性氧（ROS）的过量产生有关。我们对这些生物标志物的研究结果清楚地表明了可能对健康产生的影响。
