Sun Shulei, Bok Junsoo, Jang Yongwoo, Seo Hyemyung
Department of Molecular and Life Sciences, Institute for Precision Therapeutics, Center for Bionano Intelligence Education and Research, Hanyang University, 55 Hanyangdaehak-ro, Ansan 15588, Republic of Korea.
Department of Medical and Digital Engineering, College of Engineering, Hanyang University, Seoul 04736, Republic of Korea.
Int J Mol Sci. 2025 Mar 4;26(5):2268. doi: 10.3390/ijms26052268.
Non-invasive, non-contact, and painless methods of electrical stimulation to enhance neural function have been widely studied in recent years, particularly in the context of neurodegenerative diseases such as Alzheimer's disease (AD) and related dementias, which cause cognitive decline and other neurological symptoms. Radiofrequency (RF), which is a rate of oscillation in the range of 3 kHz to 300 GHz (3 THz), has been suggested as one potential non-contact neuronal stimulation (NCNS) technique for improving brain function. A new type of electrical stimulation uses a radiofrequency electromagnetic field (RF-EMF). RF exposure has been shown to modulate neural stimulation and influence various brain activities in in vitro and in vivo models. Recent studies have explored the effects of RF-EMF on human physiology, particularly in areas such as brain activity, cognition, and sleep behavior. In this review, we summarize recent findings about the effects of non-contact stimulations in in vitro studies, in vivo animal models, and human clinical cases.
近年来，用于增强神经功能的非侵入性、非接触式且无痛的电刺激方法得到了广泛研究，尤其是在阿尔茨海默病（AD）及相关痴呆症等神经退行性疾病的背景下，这些疾病会导致认知能力下降和其他神经症状。射频（RF），其振荡频率范围为3千赫兹至300吉赫兹（3太赫兹），已被提议作为一种潜在的非接触式神经元刺激（NCNS）技术，用于改善脑功能。一种新型的电刺激使用射频电磁场（RF-EMF）。在体外和体内模型中，已表明射频暴露可调节神经刺激并影响各种脑活动。最近的研究探讨了RF-EMF对人体生理的影响，特别是在脑活动、认知和睡眠行为等领域。在本综述中，我们总结了关于非接触式刺激在体外研究、体内动物模型和人类临床病例中的影响的最新发现。
