Pronina E V, Karaev Z O, Alferov V P
Pediatriia. 1990(5):14-8.
As many as 86 children aged 3 to 14 years with bronchial asthma were examined using mycological, immunological and allergological methods including the prick-test, basophil degranulation test (direct Shelley's test) and leukocyte migration inhibition test with Candida antigen. As far as the patients living in the vicinity of a microbiological factory are concerned, hypersensitivity to Candida was detected in 83.3% of cases, primarily that of the delayed type (37%). In children with verified candidiasis, hypersensitivity to Candida fungi was also detectable in 83.3% of cases, but in the majority of patients (47%), it was of the immediate type. In the control group, allergic candidiasis was diagnosed in 20% of cases. Clinically, bronchial asthma associated with allergic candidiasis was characterized by refractory, lingering obstructive bronchitis amenable to antimycotic drugs.
采用真菌学、免疫学和变应性学方法，包括点刺试验、嗜碱性粒细胞脱颗粒试验（直接谢利试验）以及白色念珠菌抗原白细胞迁移抑制试验，对多达86名3至14岁的支气管哮喘儿童进行了检查。就居住在微生物工厂附近的患者而言，83.3%的病例检测到对白色念珠菌过敏，主要为迟发型（37%）。在确诊为念珠菌病的儿童中，83.3%的病例也可检测到对念珠菌真菌过敏，但大多数患者（47%）为速发型。在对照组中，20%的病例诊断为变应性念珠菌病。临床上，与变应性念珠菌病相关的支气管哮喘表现为难治性、迁延性阻塞性支气管炎，抗真菌药物治疗有效。
